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New Avenue Of HIV Damage Found

Date:
October 10, 2002
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota have discovered a new process by which HIV damages the immune system. They demonstrated that the portion of lymph nodes called the T cell zone is significantly damaged by chronic inflammation, which causes fibrosis. This is important because the T cell zone is where a significant portion of the human immune response occurs. The finding of accumulation of scar tissue in this portion of the lymph node may explain why aggressive anti-retroviral therapy (ART) does not improve the immune system in some people with HIV-1 infection.

MINNEAPOLIS / ST. PAUL -- Researchers at the University of Minnesota have discovered a new process by which HIV damages the immune system. They demonstrated that the portion of lymph nodes called the T cell zone is significantly damaged by chronic inflammation, which causes fibrosis. This is important because the T cell zone is where a significant portion of the human immune response occurs. The finding of accumulation of scar tissue in this portion of the lymph node may explain why aggressive anti-retroviral therapy (ART) does not improve the immune system in some people with HIV-1 infection. The study findings will be published in the Oct. 16, 2002, issue of the Journal of Clinical Investigation. The paper can be found at http://www.jci.org.


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The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


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University Of Minnesota. "New Avenue Of HIV Damage Found." ScienceDaily. ScienceDaily, 10 October 2002. <www.sciencedaily.com/releases/2002/10/021010065809.htm>.
University Of Minnesota. (2002, October 10). New Avenue Of HIV Damage Found. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2002/10/021010065809.htm
University Of Minnesota. "New Avenue Of HIV Damage Found." ScienceDaily. www.sciencedaily.com/releases/2002/10/021010065809.htm (accessed April 17, 2014).

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