Featured Research

from universities, journals, and other organizations

U. Va. Team Identifies Gene That Could Halt Spread Of Cancer

Date:
November 15, 2002
Source:
University Of Virginia Health System
Summary:
A gene may be responsible for halting the spread of cancer through the body, according to scientists at the University of Virginia Health System. The gene, called RhoGDI2, could also be used as a warning to help catch the spread of cancer in patients earlier.

CHARLOTTESVILLE, Va., Nov. 14 – A gene may be responsible for halting the spread of cancer through the body, according to scientists at the University of Virginia Health System. The gene, called RhoGDI2, could also be used as a warning to help catch the spread of cancer in patients earlier. A multidisciplinary team of scientists, led by Dr. Dan Theodorescu, professor of urology and molecular physiology at U.Va., used advanced DNA technology to discover that low levels of RhoGDI2 were found more often in invasive cancer than in localized cancer. Their findings are published in the Nov. 15 issue of Cancer Research. This is the first study linking the RhoGDI2 gene to cancer metastasis.

Related Articles


"We found the greatest RhoGDI2 loss in invasive and metastatic cancer tissue. At this point, it is clear the gene plays a role in the cancer's lethal progression to metastasis and not in the initial formation of the cancer, " Theodorescu said. "As such, it is one of only a handful of true metastasis suppressor genes known."

To identify RhoGDI2 as a metastasis suppressor gene, the U.Va. researchers "replaced" missing RhoGDI2 genes in human metastatic cancer cells that did not manufacture the gene on their own. "We replaced the gene in the most aggressive cell lines we had in the lab," Theodorescu said. "The first thing we noticed was that the cells grew normally. We were initially disappointed until we discovered that cells with the RhoGDI2 replaced had lost the ability to metastasize."

When the RhoGDI2 gene is active in a cancer cell, Theodorescu explained, the cell produces a protein that prevents the cancer cell from invading other organs. U.Va. scientists believe a future diagnostic test for low levels of this protein could be developed. The absence of the protein could serve as a red flag for physicians and help determine which cancers have the propensity to spread. Used in combination with other prognostic tests and biomarkers, RhoGDI2 expression may help determine the most effective and least invasive treatment for each patient based on the seriousness of the cancer.

If the gene can be "awakened" in metastatic cancers using gene therapy or other approaches, Theodorescu's research could offer new therapeutic options to treat metastatic disease since once cancer metastasizes, or spreads, to other organs it is much less curable. In ongoing research, Theodorescu hopes to discover exactly how the RhoGDI2 gene regulates cell metastasis.

Scientists at U.Va. and The Genomics Institute of the Novartis Research Foundation contributing to the study were: J. J. Gildea, M. J. Seraj, G. Oxford, M. A. Harding, G. M. Hampton, C. A. Moskaluk, H. F. Frierson and M. R. Conaway. Their research was supported by the National Cancer Institute and the American Cancer Society.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "U. Va. Team Identifies Gene That Could Halt Spread Of Cancer." ScienceDaily. ScienceDaily, 15 November 2002. <www.sciencedaily.com/releases/2002/11/021115070316.htm>.
University Of Virginia Health System. (2002, November 15). U. Va. Team Identifies Gene That Could Halt Spread Of Cancer. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2002/11/021115070316.htm
University Of Virginia Health System. "U. Va. Team Identifies Gene That Could Halt Spread Of Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/11/021115070316.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins