Featured Research

from universities, journals, and other organizations

Signaling Pathway In Melanoma Could Provide Target For Diagnosis, Prevention And Treatment

Date:
December 6, 2002
Source:
Emory University Health Sciences Center
Summary:
Scientists at Emory University School of Medicine have identified a signaling pathway that is turned on when benign moles turn into early-stage malignant melanoma. The pathway could provide a new target for the diagnosis, prevention and treatment of the most lethal form of skin cancer. The research was reported in the December issue of the journal Clinical Cancer Research.

ATLANTA -- Scientists at Emory University School of Medicine have identified a signaling pathway that is turned on when benign moles turn into early-stage malignant melanoma. The pathway could provide a new target for the diagnosis, prevention and treatment of the most lethal form of skin cancer. The research was reported in the December issue of the journal Clinical Cancer Research.

A team of Emory scientists led by Jack L. Arbiser, MD, PhD, found that the signaling pathway called mitogen activated protein kinase (MAP kinase) is abnormally turned on in melanoma, particularly in its early stages. The investigators studied levels of activated MAP kinase in 131 tissue samples from precancerous moles (atypical nevi) and malignant melanomas. They found high levels of activated MAP kinase in early melanomas, but not in moles that are the precursors to melanoma.

In addition to MAP kinase activation, the Emory investigators studied two genes known to be up-regulated by the MAP kinase –– vascular endothelial growth factor (VEGF) and tissue factor (TF). These genes also are known to be powerful stimulators of angiogenesis, which is the growth of microscopic blood vessels that nourishes cancerous tumors and leads to unregulated cell growth. The development of dormant tumors into actively proliferating tumors requires angiogenesis.

Dr. Arbiser and his colleagues did not find evidence of VEGF and TF in precancerous moles, but they did find these two target genes present in early melanomas.

According to the American Cancer Society, patients who have melanoma that has not spread below the skin have a survival rate of 96 percent beyond five years. But as the tumor begins to grow, the survival rate falls to 61 percent if the disease has reached the lymph nodes below the skin and 12 percent if it has spread to other organs in the body. Melanoma is the sixth most common form of cancer in U.S. men and the seventh most common form in U.S. women. The Cancer Society estimates that 53,600 new cases of melanoma will be diagnosed in the U.S. in 2002 and that 7,400 people will die from it.

"Our finding is of interest for two reasons," Dr. Arbiser says. "First, it may help physicians determine whether a mole is malignant, which is often difficult. Second, drugs that target MAP kinase could become available as creams and help prevent the change of moles to melanomas. Our study identifies MAP kinase as a pathway that must be targeted in the prevention and treatment of melanoma."


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Signaling Pathway In Melanoma Could Provide Target For Diagnosis, Prevention And Treatment." ScienceDaily. ScienceDaily, 6 December 2002. <www.sciencedaily.com/releases/2002/12/021206074730.htm>.
Emory University Health Sciences Center. (2002, December 6). Signaling Pathway In Melanoma Could Provide Target For Diagnosis, Prevention And Treatment. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2002/12/021206074730.htm
Emory University Health Sciences Center. "Signaling Pathway In Melanoma Could Provide Target For Diagnosis, Prevention And Treatment." ScienceDaily. www.sciencedaily.com/releases/2002/12/021206074730.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins