Featured Research

from universities, journals, and other organizations

Vitamins May Protect Against Heart Disease

Date:
January 17, 2003
Source:
University Of California - Los Angeles
Summary:
A UCLA research team has discovered that a popular health supplement and antioxidant vitamins may help prevent atherosclerosis, or blockage of the blood vessels. The findings are reported in the Jan. 13 online edition of the Proceedings of the National Academy of Sciences.

A UCLA research team has discovered that a popular health supplement and antioxidant vitamins may help prevent atherosclerosis, or blockage of the blood vessels. The findings are reported in the Jan. 13 online edition of the Proceedings of the National Academy of Sciences.

"Our findings suggest that people who take dietary supplements of L-arginine, an amino acid, and antioxidants, such as vitamins C and E, might be at a lower risk for atherosclerosis and heart disease," said Dr. Louis J. Ignarro, a 1998 Nobel laureate in medicine and UCLA professor of molecular and medical pharmacology. "This is significant because cardiovascular disease is still the No. 1 cause of death in the United States."

The early lesions and cholesterol deposits that mark atherosclerosis first develop where blood vessels branch in different directions. Blood rushing around these tight corners constantly exposes cells to a pounding force, causing inflammation. As the inflamed blood vessels narrow, plaques build up inside, blocking blood flow and often leading to serious disease, such as stroke and heart attacks.

"Atherosclerotic plaques act like trash caught in a river bend, impeding the flow," Ignarro said. "But our research shows that treatment with antioxidants and L-arginine may prevent blood vessel inflammation and subsequent damage."

Ignarro's lab exposed human cells in a culture dish to varying forces of fluid flow and found that high shear stress induced inflammatory molecules. When the scientists added antioxidants and L-arginine to the cells, the production of harmful molecules decreased. In addition, this step increased production of eNOS, a molecule that promotes dilation of the blood vessels and prevents clotting.

The UCLA team also showed that combining L-arginine and antioxidants blunted the damaging effects of shear stress in a strain of mice bred with high cholesterol levels.

"It's likely that L-arginine and the antioxidants act synergistically to reduce the levels of inflammatory molecules and increase eNOS levels," Ignarro said. "Although the experiments were conducted in mice, we believe that these observations may predict the same outcome in patients who suffer from atherosclerosis and heart disease."

Co-authors included Sharon Williams Ignarro and Wulf Palinski from UCLA; Fiolmena de Nigris, Giacomo Sica and Claudio Napoli from the University of Naples; and Lilach Lerman and Amir Lerman from the Mayo Clinic.

The National Institutes of Health and the Mayo Foundation supported the research.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "Vitamins May Protect Against Heart Disease." ScienceDaily. ScienceDaily, 17 January 2003. <www.sciencedaily.com/releases/2003/01/030117081437.htm>.
University Of California - Los Angeles. (2003, January 17). Vitamins May Protect Against Heart Disease. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2003/01/030117081437.htm
University Of California - Los Angeles. "Vitamins May Protect Against Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2003/01/030117081437.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins