Featured Research

from universities, journals, and other organizations

Minnesota Researchers Identify Protein That Causes Cell Nucleoli To Disassemble

Date:
February 19, 2003
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota have identified the protein responsible for disassembly of donor nucleoli in the context of nuclear cloning. Although it was already known that nucleoli, essential structures for protein synthesis, normally disassemble or disappear for a period of time in the early animal development and also during nuclear cloning, it was not known until this study what causes this phenomenon.

MINNEAPOLIS / ST. PAUL (Feb. 14, 2003) —Researchers at the University of Minnesota have identified the protein responsible for disassembly of donor nucleoli in the context of nuclear cloning. Although it was already known that nucleoli, essential structures for protein synthesis, normally disassemble or disappear for a period of time in the early animal development and also during nuclear cloning, it was not known until this study what causes this phenomenon. Researchers hope the identification of the protein will lead to advances in cloning techniques and potential therapies. The study will be published in the journal Nature Cell Biology on Feb. 17.

“The nucleolus, one of the largest structures found within the cell’s nucleus, contains numerous proteins that have essential roles in cell biology, for cancer, stem cells, and aging,” said lead researcher Nobuaki Kikyo, M.D, Ph.D., assistant professor of medicine, Stem Cell Institute. “By understanding how the nucleolus disassembles and reassembles, we hope to learn more about normal cell development, the roles of specific proteins, and their impact on human diseases.”

In the cloning process, the genetic material is removed from an egg cell, and then the nucleus containing the genetic material from a somatic (or body-associated) cell is transplanted into the egg cell. Kikyo and his team recreated the normal procedure by mixing somatic cell nuclei and protein extract from frog eggs to purify the proteins responsible for nucleolar disassembly. Kikyo identified the proteins, FRGY2a and FRGY2b, that disassemble nucleoli without help of other proteins. The nucleoli are later reassembled as they normally would be.

“The study shows that FRGY2 proteins may be able to transform adult cells into something more like embryonic cells—young and actively proliferating cells with flexibility to turn into many types of cells,” said Kikyo. “Furthermore, this work shows that it is possible to dissect the very mysterious process – cloning – with a biochemical approach and identify key players in it.”


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Minnesota Researchers Identify Protein That Causes Cell Nucleoli To Disassemble." ScienceDaily. ScienceDaily, 19 February 2003. <www.sciencedaily.com/releases/2003/02/030219080939.htm>.
University Of Minnesota. (2003, February 19). Minnesota Researchers Identify Protein That Causes Cell Nucleoli To Disassemble. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2003/02/030219080939.htm
University Of Minnesota. "Minnesota Researchers Identify Protein That Causes Cell Nucleoli To Disassemble." ScienceDaily. www.sciencedaily.com/releases/2003/02/030219080939.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins