Featured Research

from universities, journals, and other organizations

Enzyme May Play Unexpected Role In Asthma

Date:
June 17, 2003
Source:
NIH/National Institute Of Allergy And Infectious Diseases
Summary:
In a finding that could have important implications for the millions of Americans who suffer from asthma, researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID) have discovered novel sets of genes possibly involved in the disease.

In a finding that could have important implications for the millions of Americans who suffer from asthma, researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID) have discovered novel sets of genes possibly involved in the disease. Their study has also revealed what the scientists believe is a key role for the enzyme arginase in causing asthmatic symptoms. The research, led by Marc E. Rothenberg, M.D., Ph.D., of Cincinnati Children's Hospital Medical Center, opens the possibility of developing new anti-asthma drugs to block arginase activity.

Asthma is on the rise in the United States and causes at least 5,000 deaths a year. Although the subject of intense study, the condition remains poorly understood at the fundamental level. Dr. Rothenberg and his colleagues used mouse models of asthma along with "gene chip" technology to probe the underpinnings of asthma. "We've identified nearly 300 mouse genes, which we call asthma signature genes, that appear to be involved in asthma pathogenesis," notes Dr. Rothenberg. "This gives us an unprecedented insight into the orchestration of the large number of genes that give rise to asthma."

The findings, published in the current issue of Journal of Clinical Investigation, appear to apply in humans as well, says Dr. Rothenberg. If confirmed through further study, the new knowledge could lead to asthma treatments tailored to an individual patient's disease.

"NIAID has long supported both basic research into asthma and the translation of such basic knowledge into more effective treatment and prevention strategies," says NIAID Director Anthony S. Fauci, M.D. "This finding is an important step towards understanding the pathogenesis of asthma, and it provides new leads to interventions that could reduce the burden of this debilitating and sometimes deadly disease."

In their quest to identify the critical genes involved in asthma, Dr. Rothenberg and his colleagues induced asthma in mice, then analyzed lung tissue with gene chips to see which genes were most active following the attacks. Two strains of asthmatic mice were evaluated following two different methods of asthma induction. A set of 496 genes was activated in the lungs of one mouse strain, while 527 genes "turned on" in the lungs of the second strain. Of these, 291 were same in both groups. The investigators called the shared genes "asthma signature genes."

The large number of genes involved in asthma--more than 6 percent of the mouse genome--same as some surprise, say lead authors Nives Zimmerman, M.D., and Nina King, Ph.D. Even more surprising, according to Dr. Rothenberg, was strong expression of genes involved in amino acid metabolism, in particular the gene encoding the enzyme arginase. Previously, arginase was thought to be limited primarily to the liver, where it helps process the amino acid arginine. "We've learned that arginase is involved in asthma regardless of the specific allergen used to induce the attack," says Dr. Rothenberg.

To learn whether arginase plays a role in human asthma as well, the scientists analyzed fluid and tissue samples from the lungs of asthmatic people and from non-asthmatic control subjects. No arginase was detected in the control samples, but significant amounts were found in the asthmatic lung. Importantly, arginase appears to be the molecule that "kicks off" the chain of action leading ultimately to asthmatic symptoms. Thus, it makes an attractive target for drug intervention. "We hope to come up with a treatment for asthma by targeting arginase," says Dr. Rothenberg.

###

NIAID is a component of the National Institutes of Health (NIH), which is an agency of the Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

Reference: N Zimmerman et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. The Journal of Clinical Investigation. 111:1863-74 (2003). doi: 10.1172/JCI200317912.

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Allergy And Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Allergy And Infectious Diseases. "Enzyme May Play Unexpected Role In Asthma." ScienceDaily. ScienceDaily, 17 June 2003. <www.sciencedaily.com/releases/2003/06/030616085202.htm>.
NIH/National Institute Of Allergy And Infectious Diseases. (2003, June 17). Enzyme May Play Unexpected Role In Asthma. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2003/06/030616085202.htm
NIH/National Institute Of Allergy And Infectious Diseases. "Enzyme May Play Unexpected Role In Asthma." ScienceDaily. www.sciencedaily.com/releases/2003/06/030616085202.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins