Featured Research

from universities, journals, and other organizations

Mouse, Stripped Of A Key Gene, Resists Diabetes

Date:
September 3, 2003
Source:
University Of Wisconsin-Madison
Summary:
An engineered mouse, already known to be immune to the weight gain ramifications of a high-calorie, high-fat diet, now seems able to resist the onset of diabetes. The mouse, stripped of a gene known as SCD-1, is apparently impervious to the negative effects of the type of diet that, for many people, has significant health and social consequences.

MADISON - An engineered mouse, already known to be immune to the weight gain ramifications of a high-calorie, high-fat diet, now seems able to resist the onset of diabetes.

The mouse, stripped of a gene known as SCD-1, is apparently impervious to the negative effects of the type of diet that, for many people, has significant health and social consequences.

"We think this animal model may be protected against diabetes," says James Ntambi, a University of Wisconsin-Madison professor of biochemistry and Steenbock professor of nutrition, and the senior author of a report describing the remarkable mouse in this week's (Sept. 1) online editions of the Proceedings of the National Academy of Sciences (PNAS).

The new finding is important because it provides critical genetic and biochemical clues to diet, obesity and the onset of a disease that affects as much as 6 percent of the U.S. population.

Type II diabetes, which accounts for about 90 percent of the incidence of diabetes in the United States, is a chronic disease caused by a problem in the way the body makes or uses insulin. Insulin is a hormone secreted by the pancreas that, under healthy circumstances, plays an essential role in moving glucose from blood to cells where the sugar's energy is expended.

In many instances, obesity and diabetes go hand in hand. Between 75 and 80 percent of people with type II diabetes are obese, although the disease can also develop in lean people, especially the elderly.

The discovery of a gene that seems to exercise significant influence over both weight gain and glucose regulation promises a potentially significant window into both conditions and their relationship. The gene makes an enzyme called SCD. It affects the production of fatty acids, and because humans have SCD-1 equivalents, the new finding helps explain why some people, who may lack the gene, remain lean and diabetes free, despite a rich, fatty diet.

"We are beginning to suspect that obese individuals have increased expression of this enzyme," says Ntambi. "If you reduce expression of this enzyme, you reduce fat expression in muscle."

This new insight into the gene and its influence could herald the development of new drugs to prevent both diabetes and obesity as it may help scientists zero in on the underlying problems that lead to both conditions.

In the engineered mice, the Wisconsin team observed that muscle cells were more sensitive to insulin, enabling the cells to absorb glucose and avoid hyperglycemia. Elevated levels of glucose in the blood prompt the pancreas to produce more insulin, which tends to make cells even more resistant to the critical hormone.

"In this animal, there is increased insulin signaling or sensitivity," Ntambi explains. "When insulin binds to the cell's insulin receptor, it triggers a cascade of events " that enables the animal to successfully regulate levels of blood sugar.

"There are lots of steps involved in the process, and in the case of type II diabetes things go wrong in some of those events," Ntambi says. "What we found in these animals is that the insulin signaling steps in muscle are all enhanced, despite low levels of insulin in plasma. We don't see a defect yet."

The work by the Wisconsin team was funded primarily by the National Institutes of Health and in part by a grant from Xenon Genetics, Inc.

In addition to Ntambi, co-authors of the PNAS report include Shaikh Mizanoor Rahman, Agnieszka Dobrzyn, Pawel Dobrzyn, Seong-Ho Lee and Makoto Miyazaki.


Story Source:

The above story is based on materials provided by University Of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University Of Wisconsin-Madison. "Mouse, Stripped Of A Key Gene, Resists Diabetes." ScienceDaily. ScienceDaily, 3 September 2003. <www.sciencedaily.com/releases/2003/09/030903074002.htm>.
University Of Wisconsin-Madison. (2003, September 3). Mouse, Stripped Of A Key Gene, Resists Diabetes. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2003/09/030903074002.htm
University Of Wisconsin-Madison. "Mouse, Stripped Of A Key Gene, Resists Diabetes." ScienceDaily. www.sciencedaily.com/releases/2003/09/030903074002.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins