Featured Research

from universities, journals, and other organizations

McMaster University Researchers Race To SARS Vaccine Development

Date:
October 2, 2003
Source:
McMaster University
Summary:
Researchers at McMaster University have turned a corner in the race to develop a vaccine for severe acute respiratory syndrome (SARS). A breakthrough has come with the work by professor Jim Mahony who cloned the gene that marks an important nuclear protein of the SARS virus.

Hamilton, ON (October 1, 2003) -- Researchers at McMaster University have turned a corner in the race to develop a vaccine for severe acute respiratory syndrome (SARS).

A breakthrough has come with the work by professor Jim Mahony who cloned the gene that marks an important nuclear protein of the SARS virus. A research team at McMaster then inserted the nuclear protein gene into an engineered common cold virus, or adenovirus vector, and will shortly test this in animals for the protective effects.

The team, headed by Jack Gauldie, chair of the department of pathology and molecular medicine and director of the Centre for Gene Therapeutics, includes professors Frank Graham, Mary Hitt and Mahony of the department of pathology and molecular medicine, along with professor Ludvik Prevec and technologist Uma Sankar of the department of biology.

Mahony's discovery was made using DNA sequence data from the SARS Vaccine Initiative (SAVI) of the British Columbia Centre for Disease Control, one of several laboratories the McMaster team is working with to develop a SARS vaccine based on the adenovirus vector that would act as a carrier within the body.

The McMaster group is also working with the SARS Initiative of the Canadian Institutes for Health Research (CIHR) and the National Centres of Excellence in Vaccine and Immunotherapy (CANVAC).

"This is an important step that will allow us to immediately determine whether we can provide protection against this virus with proper immunization," said Gauldie.

Dr. Mark Loeb, director of the Canadian SARS Research Network, says the discovery is an excellent next step in the development of a SARS vaccine.

"SARS is a deadly disease, particularly dangerous to those with compromised health," said Loeb, who is also an infectious disease specialist at McMaster University. "The development of a vaccine is important in ensuring Canadians are better protected against a reoccurrence of the syndrome."

Through the SAVI collaboration, the McMaster team obtained genes that encode important markers of the SARS virus. As a vaccine these genes are inserted into the backbone of the adenovirus that could then be administered directly to humans to produce a protective immune response.

Since SARS is a respiratory virus, the response must protect the lung surface from infection. Adenovirus vaccines are excellent candidates for this mucosal vaccine approach. In addition to generating strong antibody responses, the modified virus vaccine can also add lymphocyte-mediated protection, an important component of the body's defence system that seeks and destroys viral-infected cells.

The McMaster team is well connected to carry out this cutting edge research. Recently supported by the Ontario Research and Development Challenge Fund initiative to provide new vectors for gene therapy, the team is known around the world for their expertise in immunology and vaccine development.

With SAVI, the McMaster team has also produced a second SARS vaccine candidate. Depending on the outcome of the animal studies, both potential vaccines could be ready to test in human trials within the year.


Story Source:

The above story is based on materials provided by McMaster University. Note: Materials may be edited for content and length.


Cite This Page:

McMaster University. "McMaster University Researchers Race To SARS Vaccine Development." ScienceDaily. ScienceDaily, 2 October 2003. <www.sciencedaily.com/releases/2003/10/031002054648.htm>.
McMaster University. (2003, October 2). McMaster University Researchers Race To SARS Vaccine Development. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2003/10/031002054648.htm
McMaster University. "McMaster University Researchers Race To SARS Vaccine Development." ScienceDaily. www.sciencedaily.com/releases/2003/10/031002054648.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins