Featured Research

from universities, journals, and other organizations

TIGR Posts Sequence Data For Parasite That Causes Trichomoniasis

Date:
October 6, 2003
Source:
The Institute For Genomic Research
Summary:
Scientists at The Institute for Genomic Research (TIGR) are beginning to unravel the mysteries of the most prevalent human parasite in North America, Trichomonas vaginalis. On October 1, TIGR released the first draft assembly of the T. vaginalis genome into the public domain.

Rockville, MD – Scientists at The Institute for Genomic Research (TIGR) are beginning to unravel the mysteries of the most prevalent human parasite in North America, Trichomonas vaginalis. On October 1, TIGR released the first draft assembly of the T. vaginalis genome into the public domain.

One surprising result of the initial research is that the parasite's genome, at between 80 million and 90 million DNA base pairs, is more than five times larger that had been estimated before the sequencing project began. Although the genome is not yet completed, TIGR is releasing data at regular intervals during the sequencing process for the scientific community.

T. vaginalis is the most prevalent parasite in North America, where it is responsible for approximately 5 million cases of vaginitis each year. As a result of sequencing the genome, researchers are now starting to understand some aspects of the sexually-transmitted parasite's biology.

"Identifying the complete gene set of the parasite should help researchers find new ways to treat or prevent the disease" says Jane Carlton, TIGR's lead investigator in the T. vaginalis project, which is being funded by the National Institute of Allergy and Infectious Diseases (NIAID) under cooperative agreement U01 AI050913.

Noting that scientists were surprised by the actual size of the parasite's genome, Carlton says analysis of the data should help determine "whether the genome's size results from a large number of genes or a large number of highly repetitive sequences."

T. vaginalis is of special interest to biomedical researchers because it is emerging as an important factor in facilitating HIV transmission, for example in African-American communities of the United States. Individuals infected with T. vaginalis have a significantly increased incidence of HIV transmission made possible by an aggressive immune response and a heavy influx of target cells for HIV. This response may increase the chance of entry of HIV in HIV-negative individuals. Conversely, in HIV-positive individuals, the hemorrhages that are frequently associated with T. vaginalis infection tend to worsen shedding and subsequent transmission of the virus.

In addition to its role in HIV infection, trichomoniasis is also associated with pre-term delivery, low birth-weight, increased infant mortality and predisposition to cervical cancer. Given its prevalence and the role that T. vaginalis plays in several serious medical concerns, the ability to rapidly identify potential vaccine candidates for T. vaginalis, using genomic sequence, is a priority in the research community.

The Trichomonas genome sequence is also expected to deepen the understanding of several other human pathogens. T. vaginalis is a member of a group of organisms called the amitochondriates, which do not use oxygen for metabolism. Other members of that group include Giardia lamblia, which causes traveler's diarrhea, and Entamoeba histolytica, which causes amebiasis. Various species of Entamoeba are now being sequenced by scientists at TIGR (http://www.tigr.org/tdb/e2k1/eha1/ ).

###

Carlton is TIGR's lead investigator on the T. vaginalis project, which is being carried out in collaboration with Patricia Johnson of the University of California-Los Angeles' Department of Microbiology, Immunology and Molecular Genetics.

The newly released sequence data can be obtained from the TIGR website at the following link: http://www.tigr.org/tdb/e2k1/tvg

The Institute for Genomic Research (TIGR), which sequenced the first complete genome of a free-living organism in 1995, is a not-for-profit research institute based in Rockville, Maryland. TIGR conducts research involving the structural, functional, and comparative analysis of genomes and gene products in viruses, bacteria, archaea, and eukaryotes.


Story Source:

The above story is based on materials provided by The Institute For Genomic Research. Note: Materials may be edited for content and length.


Cite This Page:

The Institute For Genomic Research. "TIGR Posts Sequence Data For Parasite That Causes Trichomoniasis." ScienceDaily. ScienceDaily, 6 October 2003. <www.sciencedaily.com/releases/2003/10/031006065239.htm>.
The Institute For Genomic Research. (2003, October 6). TIGR Posts Sequence Data For Parasite That Causes Trichomoniasis. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2003/10/031006065239.htm
The Institute For Genomic Research. "TIGR Posts Sequence Data For Parasite That Causes Trichomoniasis." ScienceDaily. www.sciencedaily.com/releases/2003/10/031006065239.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins