Featured Research

from universities, journals, and other organizations

Researchers Discover New Genetic Link To Common Colon Cancer

Date:
October 14, 2003
Source:
University Hospitals Of Cleveland
Summary:
A team of researchers from University Hospitals of Cleveland (UHC) and Case Western Reserve University have identified a specific location on a human chromosome that can be linked to familial cases of colon cancer--the type of colon cancer that tends to run in families.

CLEVELAND, October 13, 2003 -- A team of researchers from University Hospitals of Cleveland (UHC) and Case Western Reserve University have identified a specific location on a human chromosome that can be linked to familial cases of colon cancer--the type of colon cancer that tends to run in families.

Related Articles


Research published today in the Proceedings of the National Academy of Sciences (PNAS article #2286) identifies a specific stretch of DNA on chromosome 9 that houses a "susceptibility" gene. "Previous studies have shown that colon cancer risk can be inherited," says Sanford Markowitz, MD, principal investigator for the study. "By analyzing blood samples from 53 families, in which at least one member of the family had a colon cancer or pre-cancerous colon polyp, we were able to find a common link. This moves us much closer to developing a blood test that will identify people who are susceptible to colon cancer well before the cancer ever develops." Dr. Markowitz is a professor of cancer genetics at Case, a Howard Hughes Medical Institute investigator, and treats patients at University Hospitals Ireland Cancer Center.

Georgia Wiesner, MD, Director of the Center for Human Genetics at UHC and Case, and lead author of the study, notes that at least 200 genes exist on this particular location on chromosome 9. "Future research will focus on finding the one responsible gene," says Dr. Wiesner. "The research team is looking for more sibling pairs and family members for the crucial next phase of the study, the actual identification of the disease-causing gene."

In addition to Drs. Markowitz and Wiesner, the research team included Robert Elston, PhD, of the Department of Epidemiology and Biostatistics at Case, and Joseph Willis, MD, of the Department of Pathology at Case and UHC.

More than six years ago, Cleveland researchers began to recruit study participants who had at least one sibling affected with colorectal cancer or large colon polyps (adenomas, which are precursors to cancer) before the age of 65. Participants provided a sample of blood and underwent colon cancer screening. In some cases, study participants who had no symptoms of disease were discovered to have pre-cancerous polyps, and had them removed. Thus, participation in the study itself actually helped some high-risk patients avoid developing colon cancer.

Colon cancer is the second leading cause of cancer death among Americans. Studies have shown that nearly 30% of adults over age 50 have non-symptomatic polyps in the colon, precursors to cancer. Studies also show that brothers and sisters of individuals with colon polyps or cancer have triple the average risk for developing colon cancer themselves.

Previously, researchers at University Hospitals of Cleveland and Case discovered a genetic link to a rare form of colon cancer called Hereditary Nonpolyposis Colon Cancer (HNPCC) that tends to develop in young adults in certain families. The just-published study was designed to identify a genetic connection in more common colon cancers. The "Colon Cancer Sibling Study" combined the expertise of physicians and scientists from the departments of Genetics, Medicine (Oncology and Gastroenterology), Pathology, Epidemiology and Biostatistics at Case and UHC.

The current study received significant support from the National Cancer Institute, the National Colon Cancer Research Alliance (NCCRA) of the Entertainment Industry Foundation, and the Howard Hughes Medical Institute. Anyone interested in participating in the next phase of the "Sibling Study" should contact the Ireland Cancer Center Information Service at University Hospitals at 1-800-641-2422. The goal is to recruit 150 new families into the study to "ultimately provide identification of the putative disease gene that underlies this linkage."


Story Source:

The above story is based on materials provided by University Hospitals Of Cleveland. Note: Materials may be edited for content and length.


Cite This Page:

University Hospitals Of Cleveland. "Researchers Discover New Genetic Link To Common Colon Cancer." ScienceDaily. ScienceDaily, 14 October 2003. <www.sciencedaily.com/releases/2003/10/031014071619.htm>.
University Hospitals Of Cleveland. (2003, October 14). Researchers Discover New Genetic Link To Common Colon Cancer. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2003/10/031014071619.htm
University Hospitals Of Cleveland. "Researchers Discover New Genetic Link To Common Colon Cancer." ScienceDaily. www.sciencedaily.com/releases/2003/10/031014071619.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins