Featured Research

from universities, journals, and other organizations

Researchers Find Genetic Link To Prostate Cancer

Date:
October 15, 2003
Source:
Wake Forest University Baptist Medical Center
Summary:
Some men may be more prone to prostate cancer because a variation in a specific gene makes them more susceptible to the harmful effects of cancer-causing agents, a new study shows. The results of the study led by Wake Forest University School of Medicine researcher Jianfeng Xu, Ph.D. are published in the British Journal of Cancer.

WINSTON-SALEM, N.C. – Some men may be more prone to prostate cancer because a variation in a specific gene makes them more susceptible to the harmful effects of cancer-causing agents, a new study shows. The results of the study led by Wake Forest University School of Medicine researcher Jianfeng Xu, Ph.D. are published in the British Journal of Cancer.

Related Articles


Xu and his team, in collaboration with researchers at Johns Hopkins University, looked at variations in a gene that controls the body's response to carcinogens in the environment as well as hormones natural to the body. They found men with prostate cancer often had a different version of the gene than men who were not affected by the disease.

Scientists believe their findings may hold important clues in understanding what environmental factors may trigger the development of prostate cancer.

"Previous research suggests prostate cancer arises in certain individuals due to a combination of genetic and environmental factors," said Xu. "Our study suggests that the genetic make-up of some men leaves them more susceptible to potential carcinogens in the environment or hormones in the body that could trigger the disease."

The researchers analyzed a gene called CYPIBI, which is thought to play an important role in the development of cancer.

CYPIBI normally plays a dual role in the body and therefore has been suggested to both cause and prevent cancer. It helps the body eliminate environmental chemicals that can cause cancer but also can activate some hormones, turning them into cancer-causing agents.

Tiny variations in the gene may alter its function, say the researchers, with some increasing the cancer-causing effects of the gene and others enhancing its ability to prevent cancer.

The team looked separately at 13 variations in CYPIBI and clusters of these variations, called polymorphisms, commonly found in Caucasian male populations. They found that one cluster of variations was more common in men with prostate cancer who had no family history of the disease, while another combination appeared more frequently in men who did not have the disease.

The study suggests men with a particular gene variant have an increased risk of prostate cancer. "It's an exciting finding because we know the gene interacts with certain cancer-causing chemicals," said Xu. "Studying this more closely will bring us closer to finding out what factors in the environment or within the body may trigger the disease."

This information will help scientists better understand how changes in the gene alter its dual functions in the body, and allow them to identify people at high risk and advise them on ways to prevent the disease.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Researchers Find Genetic Link To Prostate Cancer." ScienceDaily. ScienceDaily, 15 October 2003. <www.sciencedaily.com/releases/2003/10/031015025657.htm>.
Wake Forest University Baptist Medical Center. (2003, October 15). Researchers Find Genetic Link To Prostate Cancer. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2003/10/031015025657.htm
Wake Forest University Baptist Medical Center. "Researchers Find Genetic Link To Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2003/10/031015025657.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins