Featured Research

from universities, journals, and other organizations

Gene Mutation Responsible For Crohn's Disease Inflammation Identified In Temple Study

Date:
October 16, 2003
Source:
Temple University
Summary:
A mutation in one of the genes that might be responsible for the inflammation that characterizes Crohn's disease has been identified by researchers at Temple University's School of Medicine (TUSM).

A mutation in one of the genes that might be responsible for the inflammation that characterizes Crohn's disease has been identified by researchers at Temple University's School of Medicine (TUSM).

Their study, "The mutation Ser511Asn leads to N-glycosulation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation," appears in the October 15 issue of Blood (www.bloodjournal.org).

Although the exact cause of Crohn's disease, a digestive disorder afflicting approximately 500,000 adults in the U.S., remains unknown, scientists agree that it is governed by the immune system and has a genetic component.

"Everyone has bacteria throughout their digestive tract, but in people with Crohn's disease, bacterial products activate inflammation, as well as the immune system, which leads to the debilitating symptoms of Crohn's, including diarrhea, constipation and cramps," said Robert Colman, MD, professor of medicine at TUSM and lead investigator of the study. "Since this reaction doesn't occur in everyone, we suspected that there was a genetic component."

While other researchers have found several genes that indicate an increased susceptibility to Crohn's disease, the Temple study went a step further and explored the role of genetics in causing the inflammation that characterizes the disease.

Specifically, Temple researchers identified a genetic mutation that involves one of the proteins (kininogen) known to be involved in inflammation. In a previous study, Colman demonstrated that a deficiency in this protein led to a much milder form of inflammation.

"Finding this mutation is important because we are now in a position to look for the same genetic mutations in humans, the presence of which would confirm that the protein kininogen plays an important role in the origin and development of Crohn's. We could then direct therapy toward modifying the effects of this protein," said Colman.

Temple researchers collaborated with the Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill. The study was supported by funding from the National Institutes of Health and the Crohn's and Colitis Foundation.


Story Source:

The above story is based on materials provided by Temple University. Note: Materials may be edited for content and length.


Cite This Page:

Temple University. "Gene Mutation Responsible For Crohn's Disease Inflammation Identified In Temple Study." ScienceDaily. ScienceDaily, 16 October 2003. <www.sciencedaily.com/releases/2003/10/031016063335.htm>.
Temple University. (2003, October 16). Gene Mutation Responsible For Crohn's Disease Inflammation Identified In Temple Study. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2003/10/031016063335.htm
Temple University. "Gene Mutation Responsible For Crohn's Disease Inflammation Identified In Temple Study." ScienceDaily. www.sciencedaily.com/releases/2003/10/031016063335.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins