Featured Research

from universities, journals, and other organizations

Protein Identified That May Play Central Role In Inflammatory Bowel Disease

Date:
November 12, 2003
Source:
University Of Virginia Health System
Summary:
Researchers at the University of Virginia Health System have discovered that a protein expressed by the immune system, called TL1A, is linked to inflammatory bowel disease (IBD) in patients, especially Crohn's disease.

CHARLOTTESVILLE, Va., Nov. 10 – Researchers at the University of Virginia Health System have discovered that a protein expressed by the immune system, called TL1A, is linked to inflammatory bowel disease (IBD) in patients, especially Crohn's disease. This is the first time TL1A has been linked to Crohn's. In a study involving fifty patients at U.Va., published in the Nov. 1 issue of The Journal of Immunology, the research team found that TL1A was expressed in patients suffering from IBD, but not in control patients who are disease free. The finding could lead to new treatments for people who suffer from IBD, the general name for two diseases that cause inflammation in the intestines.

Related Articles


Ulcerative colitis causes inflammation and ulcers in the top layer of the intestinal lining, usually in the lower part of the large intestine, while in Crohn's, the inflammation extends deep into the lining, usually in the small intestine. Over one million adults and children in the U.S. suffer from inflammatory bowel disease, with about 30,000 new cases diagnosed each year, according to the Crohn's and Colitis Foundation of America. Adolescents and young adults are most susceptible to IBD and there is no cure.

"What we have discovered here at U.Va. is a cytokine, a key protein that regulates the immune response, that could be an important target for therapy in IBD patients who are not responding to current treatments for ulcerative colitis and Crohn's disease," said Dr. Fabio Cominelli, principal investigator of the study, professor of internal medicine and microbiology and director of the Digestive Health Center of Excellence at U.Va. "Blocking the interaction between TL1A and its receptor in the immune response, called DR3, could be beneficial to the thousands of people suffering from chronic intestinal inflammation."

TL1A is a newly discovered member of the tumor necrosis factor (TNF) family of proteins thought to be expressed primarily in the endothelial cells that line the intestines. When TL1A interacts with DR3, found on active lymphocytes, the body can produce T cells as part of the inflammatory response associated with IBD. Anti-TNF drugs, such as Remicadeฎ, are being used to treat people with moderate to severe Crohn's symptoms that do not respond to conventional therapy.

Cominelli and his research team at U.Va. examined surgical specimens from patients with Crohn's disease and ulcerative colitis, and from non-IBD control patients, who underwent therapeutic bowel resection. The researchers found minimal quantities of TL1A in the control specimens. But TL1A was present in the tissue of IBD patients and its expression correlated with the severity of inflammation. "The more inflammation present in a specimen, the more TL1A was found," Cominelli said.

The researchers concluded that TL1A expression is significantly associated with Crohn's disease, where the protein was found in large numbers in macrophage and lymphocyte cells of the gut immune system. The study found that, in contrast, TL1A was primarily found in the plasma cells of ulcerative colitis patients, pointing to the different physiologies of the two diseases. Interestingly, TL1A expression was not found in the intestinal lining of Crohn's or ulcerative colitis patients.

Cominelli and his team at U.Va. are continuing their research into TL1A and other proteins that may play a role in inflammatory bowel disease. Earlier this year, they found that the monoclonal antibody against tumor necrosis factor (TNF) in the drug Remicadeฎ protects intestinal cells from programmed cell death and promotes healing in damaged IBD tissue.

###

The latest study involving TL1A can be accessed online at The Journal of Immunology website: http://www.jimmunol.org/cgi/content/full/171/9/4868.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Protein Identified That May Play Central Role In Inflammatory Bowel Disease." ScienceDaily. ScienceDaily, 12 November 2003. <www.sciencedaily.com/releases/2003/11/031111065616.htm>.
University Of Virginia Health System. (2003, November 12). Protein Identified That May Play Central Role In Inflammatory Bowel Disease. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2003/11/031111065616.htm
University Of Virginia Health System. "Protein Identified That May Play Central Role In Inflammatory Bowel Disease." ScienceDaily. www.sciencedaily.com/releases/2003/11/031111065616.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins