Featured Research

from universities, journals, and other organizations

Naked Mole-rats Bare Pain Relief Clues

Date:
November 17, 2003
Source:
University Of Illinois At Chicago
Summary:
East African naked mole-rats, the only known cold-blooded mammal, have shown a rather heated response in lab tests that may have important implications for treating chronic pain in humans.

East African naked mole-rats, the only known cold-blooded mammal, have shown a rather heated response in lab tests that may have important implications for treating chronic pain in humans.

The blind, furless creatures that live underground in colonies lack a body chemical called Substance P, a neurotransmitter normally in the skin that sends pain signals to the central nervous system. The rats feel no immediate pain when cut, scraped or subjected to heat stimuli. They only feel some aches. But when the rats get a shot of Substance P, pain signaling resumes working as in other mammals.

"It was a complete surprise when we discovered that the skin of naked mole-rats is missing one of the most basic chemicals that's found in the skin of all other mammals," said Thomas Park, associate professor of biological sciences at the University of Illinois at Chicago and the principal investigator in the research project.

Co-investigators include Christopher Comer, professor of biological sciences, Ying Lu, assistant professor of anesthesiology and Charles Laurito, professor of anesthesiology -- all at UIC -- along with pharmacologists Frank Rice of the Albany Medical College in Albany, N.Y. and Steven Wilson, of the University of South Carolina School of Medicine.

The findings were reported in a presentation by Lu Nov.8 in New Orleans at the annual meeting of the Society for Neuroscience.

Some medical researchers believe an excess of Substance P causes the human condition fibromyalgia, where patients suffer from chronic pain in soft fibrous body tissue such as muscles, ligaments and tendons. Theoretically, reducing or eliminating Substance P in affected areas could ease the pain. Experiments using naked mole-rats may help test this hypothesis and perhaps lead to new therapies.

"After we discovered that naked mole-rats naturally lacked Substance P, we realized that we had a unique situation whereby we could try to re-introduce this chemical to better understand its role in pain signaling," said Park.

A virus was applied to the feet of the rats to transport DNA that codes for Substance P through nerve endings on the skin. The virus then migrated over a period of a few days to nerve cells near the spinal cord where the DNA produced Substance P.

Each foot used was then anesthetized and held close to an uncomfortably warm -- but not damaging -- lamp to activate nerve fibers associated with Substance P but not other types of nerve fibers. The rats' feet treated with Substance P quickly recoiled. Those not treated also withdrew from the lamp, but much more slowly.

A key unanswered question is why naked mole-rats evolved over perhaps millions of years to have no Substance P in their skin and became oblivious to normal pain stimuli.

One possible explanation is that because these curious creatures have had to cope with high levels of carbon dioxide in their crowded underground tunnel colonies -- a condition that normally would cause the type of pain associated with Substance P in mucous membranes throughout the animals' bodies -- they have become insensitive to the pain.

Another possibility involves Substance P and blood vessel dilation in the skin -- to cool the body surface. In cold-blooded naked mole-rats, however, dilation would cause them to dangerously overheat, so they may have evolved to eliminate Substance P from their skin.

"We were surprised by how dramatic the results were," said Park. "We expected Substance P could restore some sensitivity to painful stimuli, but it was a real surprise that this single chemical could make the naked mole-rats behave just like other mammals."

Further experiments are planned with the rats to investigate how other pain systems work in the absence of Substance P.

Funding for the research was provided by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "Naked Mole-rats Bare Pain Relief Clues." ScienceDaily. ScienceDaily, 17 November 2003. <www.sciencedaily.com/releases/2003/11/031117073925.htm>.
University Of Illinois At Chicago. (2003, November 17). Naked Mole-rats Bare Pain Relief Clues. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2003/11/031117073925.htm
University Of Illinois At Chicago. "Naked Mole-rats Bare Pain Relief Clues." ScienceDaily. www.sciencedaily.com/releases/2003/11/031117073925.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins