Featured Research

from universities, journals, and other organizations

Study Shows Combining Gene Therapy And Radiation Holds Promise

Date:
November 24, 2003
Source:
Henry Ford Health System
Summary:
A novel approach that combines gene therapy and radiation therapy for treating prostate cancer has shown promising results for its safety and effectiveness, according to Henry Ford Hospital researchers.

DETROIT – A novel approach that combines gene therapy and radiation therapy for treating prostate cancer has shown promising results for its safety and effectiveness, according to Henry Ford Hospital researchers.

The study, published in this month's edition of Cancer Research, shows that patients experienced no significant side effects when treated with gene therapy and radiation therapy. It also showed that the treatment lowered patients' prostate-specific antigen (PSA) and eliminated the cancer in many of them.

PSA is a protein produced by the prostate. By measuring its level, doctors can monitor prostate cancer growth as well as the effectiveness of standard and investigational treatments.

All 15 patients enrolled in the study experienced significant declines in their PSA – from an average of 12 to below one – and 10 of them were cancer-free after one year. The patients had an aggressive form of prostate cancer that, if treated with standard radiation therapy alone, would likely recur and possibly spread.

While the results are encouraging, researchers say more research is needed and the novel treatment needs to be tested in a larger randomized clinical trial, which is planned for next year.

"Our belief is that gene therapy could make conventional cancer therapies such as radiation therapy more effective," says Svend Freytag, Ph.D., division head of Henry Ford's Radiation Oncology Research and lead author of the study.

The study is the first of its kind in the world to test the safety and effectiveness of a replication-competent virus in combination with radiation therapy. The replication-competent virus used in the treatment – the one associated with the common cold – has been shown to enhance the gene therapy's effectiveness by spreading the gene therapy to nearby cells after it is injected into the prostate.

The virus kills the cancerous cells, but leaves normal ones undamaged. When combined with the gene therapy, it enhances the virus' effect by rendering the malignant cells sensitive to radiation therapy.

An estimated 220,900 new cases of prostate cancer will be diagnosed this year, and nearly 29,000 men will die of it, according to the American Cancer Society. Prostate cancer is the second-leading cause of cancer death in men, after lung cancer.


Story Source:

The above story is based on materials provided by Henry Ford Health System. Note: Materials may be edited for content and length.


Cite This Page:

Henry Ford Health System. "Study Shows Combining Gene Therapy And Radiation Holds Promise." ScienceDaily. ScienceDaily, 24 November 2003. <www.sciencedaily.com/releases/2003/11/031124070918.htm>.
Henry Ford Health System. (2003, November 24). Study Shows Combining Gene Therapy And Radiation Holds Promise. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2003/11/031124070918.htm
Henry Ford Health System. "Study Shows Combining Gene Therapy And Radiation Holds Promise." ScienceDaily. www.sciencedaily.com/releases/2003/11/031124070918.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins