Featured Research

from universities, journals, and other organizations

Repeated Treatment Of Gum Disease Reduces Levels Of Inflammatory Factors Known To Increase Heart Disease Risk

Date:
April 8, 2004
Source:
University At Buffalo
Summary:
Reinforcing the relationship between periodontal disease and heart disease, oral biologists from the University at Buffalo have shown that levels of two inflammatory proteins known to raise the risk of heart disease can be reduced substantially by regularly treating existing gum infections.

BUFFALO, N.Y. -- Reinforcing the relationship between periodontal disease and heart disease, oral biologists from the University at Buffalo have shown that levels of two inflammatory proteins known to raise the risk of heart disease can be reduced substantially by regularly treating existing gum infections.

"You can have significant effects in other parts of the body by treating local problems," said Sara Grossi, D.D.S., senior research scientist in the Department of Oral Biology, UB School of Dental Medicine and senior author on the study. "That's why treating these infections is so important."

Results of the study were presented at the International Association for Dental Research meeting held March 10-13 in Hawaii by Owais A. Farooqi, a doctoral student working with Grossi in UB's Periodontal Disease Research Center.

The current study reports findings from 102 patients with periodontal disease who were randomized to two study groups and followed for one year. One group received standard "mechanical" treatment for periodontal disease, called scaling and root planning. The other group had the antibiotic gel Atridox™ applied to their gums before mechanical treatment.

Blood drawn at the start of the study showed that all patients had high levels of an inflammatory marker called C-reactive protein, which is known to put individuals at high risk for heart disease, and of fibrinogen, a protein involved in promoting blood clots. All patients were free of other conditions that could cause inflammatory proteins to show up in their blood stream

Both groups received their designated treatment at baseline, 3, 6 and 9 months. Blood samples were taken at baseline, and at 6 weeks, 3, 6, 9 and 12 months. At the end of 12 months, results showed that systemic levels of markers of inflammation decreased with repeated treatment.

"People who have high levels of CRP in their blood are at high risk of heart disease," Grossi said. "Our results showed that in people who had elevated levels of CRP at baseline, removal of dental plaque bacteria by scaling or scaling combined with topical antibiotics produced a statistically significant

reduction, bringing CRP levels close to the low-risk level. Both treatments also significantly reduced levels of fibrinogen in patients with elevated fibrinogen levels.

Grossi's lab next will assess levels of cytokines -- additional markers of inflammation -- and how periodontal therapy affects them. "This work will provide additional information on the systemic effect or benefit of treating gum infection and provide valuable information on the relationship between gum disease and heart disease and diabetes.

Additional researchers on the study were Alex Ho, statistician, and Robert J. Genco, D.D.S., Ph.D., SUNY Distinguished professor, from the UB Department of Oral Biology, and J. Steven Garrett from Atrix Laboratories Inc.

The research was supported by grants from the U.S. Public Health Service, National Institutes of Health and Atrix.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Repeated Treatment Of Gum Disease Reduces Levels Of Inflammatory Factors Known To Increase Heart Disease Risk." ScienceDaily. ScienceDaily, 8 April 2004. <www.sciencedaily.com/releases/2004/04/040407081610.htm>.
University At Buffalo. (2004, April 8). Repeated Treatment Of Gum Disease Reduces Levels Of Inflammatory Factors Known To Increase Heart Disease Risk. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2004/04/040407081610.htm
University At Buffalo. "Repeated Treatment Of Gum Disease Reduces Levels Of Inflammatory Factors Known To Increase Heart Disease Risk." ScienceDaily. www.sciencedaily.com/releases/2004/04/040407081610.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins