Featured Research

from universities, journals, and other organizations

Scientists Strive To Knock Out Hospital 'Superbugs'

Date:
April 23, 2004
Source:
University Of Edinburgh
Summary:
Doctors from the University of Edinburgh and local intensive care units have linked to fight an antibiotic-resistant infection which attacks some hospital patients.

Doctors from the University of Edinburgh and local intensive care units have linked to fight an antibiotic-resistant infection which attacks some hospital patients. The scientists aim to find new treatments for ventilator-associated pneumonia (VAP) at a time when bacteria resistant to antibiotics are emerging faster than the pharmaceutical industry can produce new drugs to combat hospital-acquired infections. It is estimated that as many as 20% of patients who require treatment on a ventilator machine may develop VAP and the infection is fatal in a high proportion of these patients.

The lung is known to make its own antibacterial substances, but these are overwhelmed by bacteria during severe infection. The new five-year Edinburgh study, which begins in May, will look first at the way the lung produces antibacterial substances. Researchers then hope to discover which of the lung’s natural antibiotics are most deficient during severe pneumonia and design the best ways to deliver genes producing these antibiotics to the diseased lung.

Dr John Simpson, leading the project, explained: “ We plan to boost expression of these naturally occurring genes in white blood cells which are programmed to travel from the bloodstream to the infected lung. In this way, the ‘highjacked’ blood cells will carry the antibiotic genes to exactly where they are most needed. We will take blood and samples of fluid from the lungs of patients with VAP to see if natural antibiotics and the cells which fight infection are able to function normally in their infected environment. The next step is to identify the best combination of therapeutic genes to be developed in the laboratory, in the hope that we can make the body’s cells and natural antibiotics clear severe pneumonia more efficiently. We hope that studying patients and healthy volunteers will pave the way for clinical trials of gene therapy for VAP, towards the end of the five-year programme. If successful, we could use the knowledge to tackle other hospital-acquired infections.”

Dr Simpson, a senior clinical lecturer and honorary consultant in respiratory medicine, was awarded the Sir Jules Thorn Award for Biomedical Research 2003 — the first time the award has been made to a Scottish University. The 970,000 award from the Sir Jules Thorns Charitable Trust, an independent medical research charity, will support the five year research programme.


Story Source:

The above story is based on materials provided by University Of Edinburgh. Note: Materials may be edited for content and length.


Cite This Page:

University Of Edinburgh. "Scientists Strive To Knock Out Hospital 'Superbugs'." ScienceDaily. ScienceDaily, 23 April 2004. <www.sciencedaily.com/releases/2004/04/040422225737.htm>.
University Of Edinburgh. (2004, April 23). Scientists Strive To Knock Out Hospital 'Superbugs'. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2004/04/040422225737.htm
University Of Edinburgh. "Scientists Strive To Knock Out Hospital 'Superbugs'." ScienceDaily. www.sciencedaily.com/releases/2004/04/040422225737.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins