Featured Research

from universities, journals, and other organizations

NIAID Expands West Nile Virus Treatment Trial

Date:
July 14, 2004
Source:
NIH/National Institute Of Allergy And Infectious Diseases
Summary:
The National Institute of Allergy and Infectious Diseases, one of the National Institutes of Health, has expanded its clinical trial of an experimental West Nile virus (WNV) treatment to about 60 sites throughout the United States and Canada.

The National Institute of Allergy and Infectious Diseases, one of the National Institutes of Health, has expanded its clinical trial of an experimental West Nile virus (WNV) treatment to about 60 sites throughout the United States and Canada. The multicenter trial, which opened at 36 sites last September, is expected to add about 24 new sites this summer, pending internal approval at each institution. A listing of all sites is available at http://www.casg.uab.edu/adult/act%20210WNV.htm.

The study is testing the safety and preliminary effectiveness of using a product containing WNV infection-fighting proteins, or antibodies, to treat people whose infection has reached or threatens to reach the brain.

"As West Nile virus disease continues to spread across our country, it is critical that we develop specific treatments for its most severe symptoms," says Anthony S. Fauci, M.D., NIAID director. "At present, clinicians have few options besides supportive care for treating people with WNV illness. By expanding this study, we hope to accelerate NIAID's efforts to understand, develop treatments for and eventually prevent this disease."

Until recently, human infection with West Nile virus, which is spread by mosquitoes, was limited to Africa, Asia and the Middle East. Since its arrival in the New York City area in 1999, human WNV infection has increased in scope and severity in the United States each year. In 2003, the U.S. Centers for Disease Control and Prevention reported more than 9,860 cases of WNV disease, which included 264 deaths. Thus far in 2004, 78 cases of WNV, including 1 death, have been reported in eight states.

The main goal of this study, notes Walla Dempsey, Ph.D., who oversees NIAID's WNV clinical trial contracts, is to assess the safety of a blood plasma-derived substance containing WNV antibodies when given intravenously to patients with WNV infection. Secondarily, she adds, the study seeks preliminary data about the treatment's effectiveness against encephalitis, a brain inflammation caused by WNV infection.

"Information from this study will enable us to better characterize the clinical course of West Nile virus infection," Dr. Dempsey says, "which in turn will allow us to design more meaningful clinical trials in the future."

The Israeli company Omrix is providing its product, Omr-IgG-am TM, for use in the trial. West Nile virus has circulated in Israel for decades, and many Israeli blood donors have antibodies to the virus. The company's product is based on WNV antibodies derived from Israeli donors who have high levels of these antibodies.

The trial can enroll up to 110 patients 18 years old and older who have WNV-related encephalitis or are who at risk of developing this severe neurological complication. Participants will receive a single dose of Omr-IgG-amTM or a dose of one of two placebos.

Participants are being recruited through NIAID's Collaborative Antiviral Study Group (CASG), headed by Richard Whitley, M.D., of the University of Alabama at Birmingham. Information about the trial is located both at CASG's Web site (http://www.casg.uab.edu) and at clinicaltrials.gov (http://www.clinicaltrials.gov/show/NCT00068055).

###

NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies.

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Allergy And Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Allergy And Infectious Diseases. "NIAID Expands West Nile Virus Treatment Trial." ScienceDaily. ScienceDaily, 14 July 2004. <www.sciencedaily.com/releases/2004/07/040714090112.htm>.
NIH/National Institute Of Allergy And Infectious Diseases. (2004, July 14). NIAID Expands West Nile Virus Treatment Trial. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2004/07/040714090112.htm
NIH/National Institute Of Allergy And Infectious Diseases. "NIAID Expands West Nile Virus Treatment Trial." ScienceDaily. www.sciencedaily.com/releases/2004/07/040714090112.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins