Featured Research

from universities, journals, and other organizations

Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth

Date:
September 1, 2004
Source:
University Of Illinois At Urbana-Champaign
Summary:
A well-known anti-cancer agent in certain vegetables has just had its reputation enhanced. The compound, in broccoli and other cruciferous vegetables, has been found to be effective in disrupting late stages of cell growth in breast cancer.

Keith Singletary, above, and doctoral student Steven Jackson report their finding involving sulforaphane (SUL), which they say could ultimately be used to enhance the prevention and treatment of breast cancer, in the September issue of the Journal of Nutrition.
Credit: Photo courtesy of University Of Illinois At Urbana-Champaign

CHAMPAIGN, Ill. -- A well-known anti-cancer agent in certain vegetables has just had its reputation enhanced. The compound, in broccoli and other cruciferous vegetables, has been found to be effective in disrupting late stages of cell growth in breast cancer.

Keith Singletary and doctoral student Steven Jackson of the University of Illinois at Urbana-Champaign report their finding involving sulforaphane (SUL), which they say could ultimately be used to enhance the prevention and treatment of breast cancer, in the September issue of the Journal of Nutrition.

"This is the first report to show how the naturally occurring plant chemical sulforaphane can block late stages of the cancer process by disrupting components of the cell called microtubules," said Singletary, a professor in the department of food science and human nutrition. "We were surprised and pleased to find that SUL could block the growth of breast cells that were already cancerous."

SUL is abundant in such vegetables as broccoli, brussels sprouts and kale. Chewing causes the cell walls of these vegetables to break, and SUL is released into the body.

Singletary, a researcher in phytochemicals and cancer chemoprevention, and Jackson exposed cultures of malignant human breast cancer cells to SUL. Within hours, SUL blocked cell division and disrupted microtubules, which are long, slender cylinders made up of tubulin (protein), that are essential for the separation of duplicated chromosomes during cell division.

"It is not yet clear whether the doses required to produce inhibition of tubulin polymerization are higher than those achievable via dietary intakes," wrote Jackson and Singletary. "However, the results show that tubulin disruption may be an important explanation for SUL's antiproliferative action."

"These findings are significant since SUL's actions appear similar to a group of anticancer drugs currently in use, such as Taxol," Singletary said.

SUL is studied extensively for its effects against cancer. Previous reports have shown that SUL induces defensive mechanisms that are effective in protecting normal cells from the initiation of cancer. "More than 10 years ago, researchers at Johns Hopkins University reported that SUL is a potent inducer of enzyme systems that can defend against carcinogens," Singletary said. Such defense mechanisms are effective during the early stage of cancer.

The Illinois research extends the 1992 discovery at Johns Hopkins and pinpoints how SUL works during later stages of cancer, such that SUL can suppress the orderly division process in human breast cancer cells.

"The findings may be helpful in the development of new breast cancer prevention and treatment strategies," Singletary said. "For example, it may be possible that ingesting SUL in combination with certain natural compounds or drugs could enhance their anticancer effectiveness and reduce side effects."

According to the American Cancer Society, breast cancer this year will account for 15 percent of all cancer deaths in women, and approximately 275,000 new breast cancer cases of various forms will be diagnosed.

Improvements in treatments such as chemotherapy have led to an 88 percent survival rate in Caucasian women and a 74 percent survival rate in African-American women, according to the most recent ACS survey in 2003.

However, some current chemotherapy drugs have side effects that have the ACS and other organizations seeking new strategies that combine chemotherapy drugs with other treatments to potentially lessen the toxic effects.

The new Illinois study confirms a previous study in mice. In the February 2004 issue of the journal Carcinogenesis, Singletary and Jackson reported that SUL treatments in mice with implanted cancer cells resulted in decreased tumor size.

More research is needed to assess SUL's potential in countering breast cancer development, Singletary said. "What we do not know is how specific SUL and other similar phytochemicals are toward cancer cells compared to normal cells," he said. "We also do not know against which cancers SUL's microtubule-targeting actions are most effective."

Future studies in Singletary's lab will address those issues.

The University of Illinois Agricultural Experiment Station and the U.S. Department of Agriculture funded the research.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth." ScienceDaily. ScienceDaily, 1 September 2004. <www.sciencedaily.com/releases/2004/09/040901091511.htm>.
University Of Illinois At Urbana-Champaign. (2004, September 1). Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2004/09/040901091511.htm
University Of Illinois At Urbana-Champaign. "Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth." ScienceDaily. www.sciencedaily.com/releases/2004/09/040901091511.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins