Featured Research

from universities, journals, and other organizations

British Columbia Researchers Aim To Create 'Living Glue' For Replacement Joints

Date:
September 15, 2004
Source:
University Of British Columbia
Summary:
By combining stem cell science with orthopedic surgery, a team of researchers at the University of British Columbia and Vancouver Coastal Health Research Institute aims to reduce the 10 per cent failure rate in hip replacements and make repeat replacements and other joint repairs obsolete within 10-15 years.

By combining stem cell science with orthopedic surgery, a team of researchers at the University of British Columbia and Vancouver Coastal Health Research Institute aims to reduce the 10 per cent failure rate in hip replacements and make repeat replacements and other joint repairs obsolete within 10-15 years.

Related Articles


With $1.5 million over five years in funding from the Canadian Institutes for Health Research, a group of seven UBC scientists will explore how stem cells – the body's "master cells" that can reproduce and develop many mature functional cells – can be used to regenerate bone cells to better secure artificial joints and other bone replacement structures. "We're very excited about the potential for long-term success for patients who need repeat surgery to repair or replace bone," says Fabio Rossi, UBC assistant professor of medical genetics and Canada Research Chair in Regenerative Medicine. "By using a well-understood stem cell and available technologies, we can accelerate research and have our discoveries quickly incorporated into patient care."

The team will create a new fixative mixture that combines minerals and slow-release growth factors. The mixture will be seeded with the patient's own mesenchymal stem cells – a type of stem cell that is easily extracted from adult bone marrow and capable of manufacturing bone cells and connective tissue. This "living glue" will form a strong, organic environment to secure artificial joints, vertebrae or other replacement structures where the original replacement has failed.

"Currently, these repeat replacements are difficult because considerable bone is lost as the joint gradually breaks down," says team member Tom Oxland, Canada Research Chair in Biomedical Engineering and director of The Centre for Hip Health, located at the Vancouver Coastal Health Research Institute (VCHRI). "New techniques will fill a critical need for the increasing number of people undergoing hip replacement and will also be useful for other bone loss patients." Hip fracture is one of the most common problems leading to bone loss and currently there is a 10 per cent failure rate in the 20,000 hip replacements performed annually in Canada. Problems include breakdown of the acrylic glue used to secure the prosthetic joint and weakened or damaged tissue surrounding the joint.

Team members include Don Brunette, associate dean, Research, Faculty of Dentistry; Pharmaceutical Sciences Prof. Helen Burt; Orthopedics Dept. Head Clive Duncan; Applied Science Assistant Prof. Goran Fernlund and Orthopedics Engineering post-doctoral fellow Hanspeter Frei.

CIHR is the major federal agency responsible for funding health research in Canada. Canada Research Chairs are federally funded research positions designed to build Canada's research capacity.

VCHRI is a joint venture between UBC and Vancouver Coastal Health that promotes development of new researchers and research activity.

Rossi's laboratory is supported by major funding from the Canada Foundation for Innovation and the B.C. Knowledge Development Fund.


Story Source:

The above story is based on materials provided by University Of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University Of British Columbia. "British Columbia Researchers Aim To Create 'Living Glue' For Replacement Joints." ScienceDaily. ScienceDaily, 15 September 2004. <www.sciencedaily.com/releases/2004/09/040915112918.htm>.
University Of British Columbia. (2004, September 15). British Columbia Researchers Aim To Create 'Living Glue' For Replacement Joints. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2004/09/040915112918.htm
University Of British Columbia. "British Columbia Researchers Aim To Create 'Living Glue' For Replacement Joints." ScienceDaily. www.sciencedaily.com/releases/2004/09/040915112918.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins