Featured Research

from universities, journals, and other organizations

Spinal Cord Nerve Regeneration Occurs In Absence Of Nogo Receptor

Date:
November 5, 2004
Source:
Yale University
Summary:
Mice engineered without the Nogo-66 Receptor (NgR) grew new nerve fibers after spinal cord injury, pointing to this receptor as a target for development of a drug to promote fiber recovery, according to a Yale study published today in Neuron.

New Haven, Conn. -- Mice engineered without the Nogo-66 Receptor (NgR) grew new nerve fibers after spinal cord injury, pointing to this receptor as a target for development of a drug to promote fiber recovery, according to a Yale study published today in Neuron.

Related Articles


The researchers led by Stephen Strittmatter, M.D., professor of neurology and neurobiology at Yale School of Medicine, found that myelin fractions from the brain were not able to block the regrowth of nerve fibers in mice lacking the Nogo-66 Receptor protein. Myelin is the protective insulation surrounding nerve fibers of the central nervous system and loss of myelin interferes with the transmission of nerve signals. However, myelin also prevents fiber regeneration after injuries to the brain or spinal cord.

While brainstem neuronal populations show strong regenerative growth of fibers into the distal spinal cord when NgR is absent, not all fiber systems grow in the adult spinal cord. The long nerve fibers of the cortico-spinal tract that reach from the brain to the spinal cord to directly control movement did not regenerate in NgR mice after spinal cord injury.

Strittmatter said he and his colleagues will now look at the best pharmacological pathways to block the function of the Nogo-66 Receptor, and also examine whether the new fiber growth might somehow change the behavior of the animal or otherwise have subtle adverse effects. There is no indication yet of any side effects from blocking the receptor.

Co-authors included Ji-Eun Kim, Betty Liu, and James Park, all of Yale.

Citation: Neuron, Vol. 44, pp 1-20 (October 28, 2004)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Spinal Cord Nerve Regeneration Occurs In Absence Of Nogo Receptor." ScienceDaily. ScienceDaily, 5 November 2004. <www.sciencedaily.com/releases/2004/10/041030213927.htm>.
Yale University. (2004, November 5). Spinal Cord Nerve Regeneration Occurs In Absence Of Nogo Receptor. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2004/10/041030213927.htm
Yale University. "Spinal Cord Nerve Regeneration Occurs In Absence Of Nogo Receptor." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030213927.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins