Featured Research

from universities, journals, and other organizations

Antioxidant Supplementation May Reduce Incidence Of Cancer In Men

Date:
November 23, 2004
Source:
Journal Of The American Medical Association
Summary:
Low-dose antioxidant supplementation may reduce the risk of cancer among men, but not in women, according to an article in the November 22 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

CHICAGO – Low-dose antioxidant supplementation may reduce the risk of cancer among men, but not in women, according to an article in the November 22 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

According to the article, antioxidants including beta carotene, ascorbic acid, vitamin E, selenium, and zinc may prevent some of the harmful effects caused by free radicals – reactive molecules produced by metabolism in the body. It has also been suggested that a low dietary intake of antioxidants increases the incidence of cancer and cardiovascular disease.

Serge Hercberg, M.D., Ph.D., of the Institut National de la Sante et de la Recherche Medicale (INSERM) and Unite de Surveillance et d'Epidemiologie Nutritionnelle, Paris, and colleagues tested the efficacy of dietary supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and cardiovascular disease among 13,017 French adults. There were 7,876 women aged 35 to 60 years old, and 5,141 men ages 45 to 60 years old included in the study. Participants were randomly assigned to take either a daily capsule containing 120 milligrams of ascorbic acid, 30 milligrams of vitamin E, six milligrams of beta carotene, 100 micrograms of selenium, and 20 milligrams of zinc; or a placebo capsule. Participants were followed-up for a median of 7.5 years.

The researchers found no differences between the antioxidant and placebo group in terms of cancer incidence (4.1 percent of the antioxidant group vs. 4.5 percent of the placebo group), or in cardiovascular disease incidence (2.1 percent for the antioxidant group vs. 2.1 percent for the placebo group) or all-cause death (1.2 percent for the antioxidant group vs. 1.5 percent for the placebo group).

However, when the researchers looked at cancer incidence according to sex, they found a significant protective effect of the antioxidants in men, who were 31 percent less likely to develop cancer than women. A similar trend was seen in men for death rates.

"After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women. Supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene," the researchers write.

The authors conclude: "… our results suggest that an adequate and well-balanced supplementation of antioxidant nutrients, at doses that might be reached with a healthy diet that includes a high consumption of fruits and vegetables, had protective effects against cancer in men."

###

(Arch Intern Med. 2004;164:2335-2342. Available post-embargo at archinternmed.com)


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Antioxidant Supplementation May Reduce Incidence Of Cancer In Men." ScienceDaily. ScienceDaily, 23 November 2004. <www.sciencedaily.com/releases/2004/11/041123113314.htm>.
Journal Of The American Medical Association. (2004, November 23). Antioxidant Supplementation May Reduce Incidence Of Cancer In Men. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2004/11/041123113314.htm
Journal Of The American Medical Association. "Antioxidant Supplementation May Reduce Incidence Of Cancer In Men." ScienceDaily. www.sciencedaily.com/releases/2004/11/041123113314.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins