Featured Research

from universities, journals, and other organizations

Major Step Forwards For Vaccine Against Cervical Cancer

Date:
January 3, 2005
Source:
Netherlands Organization For Scientific Research
Summary:
Dutch researcher Laura Bungener has developed a vaccine against cervical cancer. Vaccinated laboratory animals no longer developed the disease and animals which had already developed a tumour, could be treated with the vaccine.

Photo of a virosome of the flu virus by using electromicroscopy. (Bungener et al. Virosome-mediated delivery of protein antigen to dendritic cells. Vaccine 20(17-18):2287-95)

Dutch researcher Laura Bungener has developed a vaccine against cervical cancer. Vaccinated laboratory animals no longer developed the disease and animals which had already developed a tumour, could be treated with the vaccine.

Cervical cancer is caused by a virus. The vaccines against cervical cancer induce an immune response to proteins from this virus, rendering it harmless. Laboratory animals which had already developed a tumour, could be treated with a vaccination.

Human papillomavirus (HPV) is the virus responsible for cervical cancer. More than one hundred types of the virus are known. Some of these are high-risk types of HPV, which can convert healthy cells into cancer cells. Proteins E6 and E7 from the virus are responsible for this and are an ideal target for treatment because they only occur in malignant cells. The vaccine developed by Bungener, induces a specific immune response against these two proteins.

To test the vaccine, Bungener administered two different vaccines to mice. The 'recombinant Semliki Forest virus' and virosomes from the flu virus. The 'recombinant Semliki Forest virus' induces the production of proteins E6 and E7. The virosomes from the flu virus contain the E7 protein.

Both vaccines induced an immune response in mice against these proteins. During the immune response, the animals produce cytotoxic T-lymphocytes that are specific for E6 and E7 and prevent the tumour from growing further. Even mice that already had a tumour could be treated with a vaccination of the 'recombinant Semliki Forest virus'.

Bungener also investigated the mechanism underlying the vaccinations by using model proteins in 'recombinant Semliki Forest virus' and in the virosomes.

The research was funded by the Netherlands Organisation for Scientific Research.


Story Source:

The above story is based on materials provided by Netherlands Organization For Scientific Research. Note: Materials may be edited for content and length.


Cite This Page:

Netherlands Organization For Scientific Research. "Major Step Forwards For Vaccine Against Cervical Cancer." ScienceDaily. ScienceDaily, 3 January 2005. <www.sciencedaily.com/releases/2004/12/041219153139.htm>.
Netherlands Organization For Scientific Research. (2005, January 3). Major Step Forwards For Vaccine Against Cervical Cancer. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2004/12/041219153139.htm
Netherlands Organization For Scientific Research. "Major Step Forwards For Vaccine Against Cervical Cancer." ScienceDaily. www.sciencedaily.com/releases/2004/12/041219153139.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins