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Oxidants Link Obesity To Diabetes

Date:
December 20, 2004
Source:
Journal Of Clinical Investigation
Summary:
Individuals with the metabolic syndrome are at risk of coronary heart disease, stroke, vascular disease, and type 2 diabetes. Although risk factors for this syndrome are known to include obesity, physical inactivity, and genetic factors, the mechanistic role of obesity is not completely understood.

Individuals with the metabolic syndrome are at risk of coronary heart disease, stroke, vascular disease, and type 2 diabetes. Although risk factors for this syndrome are known to include obesity, physical inactivity, and genetic factors, the mechanistic role of obesity is not completely understood. In the December 15 issue of the Journal of Clinical Investigation, Iichiro Shimomura and researchers from Osaka University, Japan, show that fat cells of obese mice produce increased levels of toxic oxygen molecules known as reactive oxygen species (ROS) as well as the enzyme NADPH oxidase. Furthermore, these cells express decreased levels of antioxidative enzymes that are responsible for destroying these toxic forms of oxygen. The effect of this oxidative stress causes changes in the production of fat-derived hormones known as adipocytokines.

The authors found that treatment of these mice with apocynin – an antioxidant that inhibits NADPH oxidase – reduced ROS production in fat cells, restored adipocytokine production to normal, improved diabetes, and reduced the levels of fat present in the blood and liver.

The results suggest that accumulated fatty tissue is a major source of ROS in obesity and acts as an early trigger of the metabolic syndrome. While it is too early to suggest that taking antioxidants may counter the development of obesity-associated metabolic syndrome, the steps leading to excess ROS generation may represent a potentially useful therapeutic target.


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Journal Of Clinical Investigation. "Oxidants Link Obesity To Diabetes." ScienceDaily. ScienceDaily, 20 December 2004. <www.sciencedaily.com/releases/2004/12/041219195923.htm>.
Journal Of Clinical Investigation. (2004, December 20). Oxidants Link Obesity To Diabetes. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2004/12/041219195923.htm
Journal Of Clinical Investigation. "Oxidants Link Obesity To Diabetes." ScienceDaily. www.sciencedaily.com/releases/2004/12/041219195923.htm (accessed July 24, 2014).

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