Featured Research

from universities, journals, and other organizations

New Technique May Help Detect Fetal Single Gene Disorders

Date:
February 28, 2005
Source:
Journal Of The American Medical Association
Summary:
A technique called size-fractionation performed on a sample of the mother's blood allows researchers to identify fetal DNA molecules separate from maternal DNA as a way to determine which pregnancies may be at risk for genetic disorders, according to a preliminary communication in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

A technique called size-fractionation performed on a sample of the mother's blood allows researchers to identify fetal DNA molecules separate from maternal DNA as a way to determine which pregnancies may be at risk for genetic disorders, according to a preliminary communication in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

Related Articles


Currently, prenatal diagnosis of hereditary genetic disorders relies on invasive procedures, such as amniocentesis or chorionic villous sampling [prenatal test that detects genetic abnormalities], which are associated with a small, but significant risk of fetal loss, the authors provide as background information.

Ying Li, Ph.D., from University Hospital, Basel, Switzerland, and colleagues analyzed a total of 32 blood samples collected at 10 to 12 weeks gestation between February 15, 2003 and February 25, 2004 in Bari, Italy, from women with risk for Beta-thalassemia (a group of inherited blood disorders that occur with high frequency in the Mediterranean population) in their newborns immediately prior to chorionic villous sampling. Samples in which the father and mother did not carry the same mutation were examined. Four distinct point mutations of the Beta-globin gene were examined. Presence or absence of the paternal mutant allele (gene) was correctly determined in 81 percent to 100 percent of the cases with only one false-positive test.

"Our study indicates that fetal genetic traits involving point mutations can be detected from the analysis of circulatory fetal DNA in maternal plasma …" The authors write in conclusion that their approach is relatively simple, does not need complex machinery and is cost-effective. "This low-cost and use of simple equipment is especially suitable for the screening of at-risk pregnancies in developing countries."

###

(JAMA. 2005; 293:843-849. Available post-embargo at JAMA.com)

Editor's Note: This study was supported by the European Union FP6 Network of Excellence "SAFE," as well as funds from the University Women's Hospital/Department of Research, University Hospital, Basel, Switzerland. Please see the JAMA article for financial disclosures.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "New Technique May Help Detect Fetal Single Gene Disorders." ScienceDaily. ScienceDaily, 28 February 2005. <www.sciencedaily.com/releases/2005/02/050222191718.htm>.
Journal Of The American Medical Association. (2005, February 28). New Technique May Help Detect Fetal Single Gene Disorders. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2005/02/050222191718.htm
Journal Of The American Medical Association. "New Technique May Help Detect Fetal Single Gene Disorders." ScienceDaily. www.sciencedaily.com/releases/2005/02/050222191718.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins