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Licorice Licks Herpes Virus Infection

Date:
March 14, 2005
Source:
Journal Of Clinical Investigation
Summary:
Researchers demonstrate that a compound found in licorice, glycyrrhizic acid (GA), can kill cells that are latently infected with Kaposi sarcoma–associated herpes virus.

Many of the viruses that infect people can sit suppressed in cells for long periods of time, but when they are reactivated can cause painful symptoms and distress. While treatment for active infections is progressing nicely, it remains very challenging to treat latent infections. In particular, progress in treating herpesvirus latency has lagged behind.

Appearing in the March 1 print edition of the Journal of Clinical Investigation, Ornella Flore and colleagues from New York University School of Medicine show, for the first time, that it is possible to interfere with herpesvirus latency by inhibiting the expression of Kaposi sarcoma–associated herpes virus (KSHV) latent genes. KSHV is the virus that is associated with Kaposi sarcoma, a disease characterized by tumors in tissues below the surface of the skin, often found in patients with immunodeficiencies like HIV and AIDS.

These investigators demonstrate that a compound found in licorice, glycyrrhizic acid (GA), can kill cells that are latently infected with KSHV. GA induces cell death by altering levels of proteins involved in latency like LANA and v-cyclin.

The possibility that GA-like compounds might be useful in treating clinical KSHV infections is of considerable interest. GA represents the first example of an anti-viral agent that specifically targets the expression of a herpesvirus gene required to maintain the virus in the latent state. The discovery of such drugs provides an opportunity for developing novel anti-herpesvirus agents to control, and perhaps eradicating latent viral infections.

In an accompanying commentary, Jeffrey Cohen states, "a compound present in licorice may seem like an unlikely candidate for the treatment of virus-associated cancers…derivates of GA might be used in the future for treating human diseases caused by latent virus infections."


Story Source:

The above story is based on materials provided by Journal Of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Clinical Investigation. "Licorice Licks Herpes Virus Infection." ScienceDaily. ScienceDaily, 14 March 2005. <www.sciencedaily.com/releases/2005/03/050309100852.htm>.
Journal Of Clinical Investigation. (2005, March 14). Licorice Licks Herpes Virus Infection. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2005/03/050309100852.htm
Journal Of Clinical Investigation. "Licorice Licks Herpes Virus Infection." ScienceDaily. www.sciencedaily.com/releases/2005/03/050309100852.htm (accessed October 22, 2014).

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