Featured Research

from universities, journals, and other organizations

Pregnancy Complications Related To Low Levels Of Anti–Clotting Proteins

Date:
April 8, 2005
Source:
Yale University
Summary:
Recurrent miscarriage, stillbirth, preeclampsia, poor fetal growth, preterm delivery and bleeding in pregnancy are influenced by low levels of the anti–clotting proteins Z and S, Yale School of Medicine researchers report in the March issue of Journal of Thrombosis and Haemostasis.

New Haven, Conn. — Recurrent miscarriage, stillbirth, preeclampsia, poor fetal growth, preterm delivery and bleeding in pregnancy are influenced by low levels of the anti–clotting proteins Z and S, Yale School of Medicine researchers report in the March issue of Journal of Thrombosis and Haemostasis.

“Our findings will help clinicians determine early in pregnancy, which women will have healthy pregnancies and which women will develop complications,” said lead author Michael Paidas, M.D., associate professor and director of the Program for Thrombosis and Hemostasis in WomenΥs Health, Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. Paidas conducted the study with colleagues at the Bio–Reference Laboratory (Elmwood Park, New Jersey).

Low levels of a novel anti–clotting factor, protein Z, and protein S early in pregnancy may act together with other genetic clotting tendencies to adversely affect pregnancy, according to the study. Testing for these proteins can help determine which women with inherited clotting problems are at risk for pregnancy complications and how they should be treated.

The study included 103 women with normal pregnancies, 106 women with pregnancy complications, and 20 women with inherited clotting conditions, which affects about 20 percent of Caucasian women. “In early pregnancy, patients with low levels of protein Z have a four–fold higher risk of pregnancy complications,” said Paidas. “Based on our data, we speculate that protein S free antigen levels below 29 percent may be associated with clotting related pregnancy complications.”

About 15 percent of U.S. pregnancies each year are marked by complications, putting these women at higher risk for complications in future pregnancies. Paidas said this study leads the growing evidence that inherited clotting conditions can dramatically add to the risk of pregnancy complications.

Women with prior pregnancies complicated by fetal loss, preeclampsia, growth restriction or bleeding, may contact Paidas at Yale Maternal–Fetal Medicine, 203–785–5682 for testing.

Other authors on the study are D–H W. Ku, M–J. Lee, S. Manish, A. Thurston, Charles J. Lockwood and Y.S. Arkel.

Citation: Journal of Thrombosis and Haemostasis, Vol. 3, No. 3, (March 2005).


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Pregnancy Complications Related To Low Levels Of Anti–Clotting Proteins." ScienceDaily. ScienceDaily, 8 April 2005. <www.sciencedaily.com/releases/2005/03/050325222816.htm>.
Yale University. (2005, April 8). Pregnancy Complications Related To Low Levels Of Anti–Clotting Proteins. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2005/03/050325222816.htm
Yale University. "Pregnancy Complications Related To Low Levels Of Anti–Clotting Proteins." ScienceDaily. www.sciencedaily.com/releases/2005/03/050325222816.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins