Featured Research

from universities, journals, and other organizations

UT Southwestern Researchers Uncover Gene Variant That Appears To Predict Type 2 Diabetes

Date:
March 29, 2005
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center.

UT Southwestern researchers have identified a gene variant that could be a predictor for type 2 diabetes -- a possible first step in diagnosing individuals who are at risk for the disease. Drs. Manisha Chandalia (left) and Nicola Abate, associate professors of internal medicine in the Center for Human Nutrition, are study authors.
Credit: Photo courtesy of UT Southwestern Medical Center At Dallas

DALLAS - March 25, 2005 - A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center.

Their findings indicated that a variation in the gene ENPP1 was as much as 13 percent more common in people with type 2 diabetes and those at greater risk for the disease. While further studies are needed, researchers said these results suggest that the variant may serve as an important genetic marker in identifying people at risk for type 2 diabetes.

"This important study uncovers one of the genes that appears to predispose to type 2 diabetes," said Dr. Scott Grundy, director of UT Southwestern's Center for Human Nutrition and the study's senior author.

In the study available online and scheduled to appear in the April issue of Diabetes, the researchers evaluated a specific gene in three study groups - South Asians, South Asians living in Dallas and Caucasians living in Dallas. Some study subjects suffered from type 2 diabetes, others had risk factors for the disease, while still others showed no signs of diabetes or any apparent risk factors.

"The implication from our study is that if a person has this gene variation, then - without waiting for the development of insulin resistance - he or she should be encouraged to follow lifestyle changes that could help prevent the onset of diabetes," said Dr. Nicola Abate, associate professor of internal medicine in the Center for Human Nutrition and the study's lead author.

Type 2 diabetes has become a serious health problem, particularly in light of the growing number of overweight and obese individuals in the United States, Dr. Abate said. In type 2 diabetes, cells ignore available insulin (insulin resistance) and not enough insulin is produced to maintain plasma glucose within a normal range. While obesity is one of the major risk factors for type 2 diabetes, not all obese people develop type 2 diabetes nor are all type 2 diabetics overweight.

Certain ethnic populations appear to have a higher risk of developing type 2 diabetes, whether overweight or not, particularly South Asians - people originating from India, Pakistan and Bangladesh.

The study focused on 679 South Asians living in Chennai, India (of which 223 had type 2 diabetes); 1,083 South Asians living in Dallas who were new immigrants or first-generation immigrants from India, Pakistan or Bangladesh (of which 121 had type 2 diabetes); and 858 nonmigrant Caucasians living in Dallas (of which 141 were type 2 diabetics). All study participants with type 2 diabetes were required to have had diabetes onset beforeage 60.

All subjects were evaluated for diabetes and family history of diabetes, as well as overall general health, and had blood tests conducted for genetic sampling.

Results showed the presence of the ENPP1 variant in 25 percent of the nondiabetic group and in 34 percent of the diabetic group of South Asians living in India; in 33 percent and 45 percent, respectively, in the nondiabetic and diabetic South Asians in Dallas; and 26 percent and 39 percent, respectively, in the nondiabetic and diabetic Caucasians. The gene ENPP1 encodes a protein that blocks the action of insulin. The genetic variation increases the action of this protein and blocks insulin action even more.

"Earlier studies we conducted showed a propensity toward insulin resistance and type 2 diabetes in South Asians, even when they were thin," Dr. Abate said. "This study expanded that to include diabetic patients and Caucasians of European descent. It also took into account the possible influence of environmental factors by comparing South Asians in both Dallas and in Chennai.

"Consistently, we found that this gene variant in all three groups predicted diabetes."

UT Southwestern researchers plan to expand their studies to other ethnic populations, as well as further examine the specific protein involved, with the hope of eventually identifying people at risk for type 2 diabetes and developing drug therapies that could be used to prevent its onset.

"Dr. Abate's previous studies showed that abnormalities in the gene ENPP1 contributed to insulin resistance. Now, Dr. Abate and his associates have demonstrated that this gene's effects on insulin resistance have biological significance in that its abnormalities make it more likely that people will develop diabetes," Dr. Grundy said. "This study is particularly revealing because of the past difficulty in identifying diabetes-causing genes on the part of geneticists working in the diabetes field."

Other researchers involved in the study were Dr. Manisha Chandalia, associate professor of internal medicine, Beverley Adams-Huet, a faculty associate in internal medicine and a biostatistician in UT Southwestern's Center for Biostatistics and Clinical Science, and former UT Southwestern postdoctoral fellow Dr. Pankaj Satija, as well as researchers from the M.V. Diabetes Specialties Centre and Madras Diabetes Research Foundation in Gopalapuram, Chennai, India.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Uncover Gene Variant That Appears To Predict Type 2 Diabetes." ScienceDaily. ScienceDaily, 29 March 2005. <www.sciencedaily.com/releases/2005/03/050328183610.htm>.
University Of Texas Southwestern Medical Center At Dallas. (2005, March 29). UT Southwestern Researchers Uncover Gene Variant That Appears To Predict Type 2 Diabetes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/03/050328183610.htm
University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Uncover Gene Variant That Appears To Predict Type 2 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2005/03/050328183610.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins