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Newly Identified Protein May Inhibit Hepatitis Virus

Date:
April 22, 2005
Source:
American Society For Microbiology
Summary:
A newly identified family of proteins may inhibit replication of the Hepatitis B (HBV) and C (HCV) viruses say researchers from California. Their findings appear in the March 2005 issue of the Journal of Virology.
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A newly identified family of proteins may inhibit replication of the Hepatitis B (HBV) and C (HCV) viruses say researchers from California. Their findings appear in the March 2005 issue of the Journal of Virology.

Hepatitis B (HBV) and C (HCV) are viruses that infect the liver, and in some cases can cause liver failure requiring a transplant for survival. The protein interferon, produced by animal cells when they are invaded by viruses, is released into the bloodstream or intercellular fluid to induce healthy cells to manufacture an enzyme that counters the infection. One class of interferons (alpha) is used to treat chronic infection with HBV and HCV. There is a vaccine available to prevent the spread of HBV but not HCV.

In the study, a new class of interferons, interferon lambda, was tested for its ability to inhibit HBV and HCV replication. Results showed 90% inhibition of HBV after twenty-four hours and 90-99% inhibition in HCV five days posttreatment.

“We have demonstrated here that replication of HBV and HCV is sensitive to the antiviral activities of interferon lambda,” say the researchers. “These results suggest the possibility that interferon lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection.”

(M.D. Robek, B.S. Boyd, F.V. Chisari. 2005. Lambda interferon inhibits hepatitis B and C virus replication. Journal of Virology, 79. 6: 3851-3854.)


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The above post is reprinted from materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


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American Society For Microbiology. "Newly Identified Protein May Inhibit Hepatitis Virus." ScienceDaily. ScienceDaily, 22 April 2005. <www.sciencedaily.com/releases/2005/04/050419105339.htm>.
American Society For Microbiology. (2005, April 22). Newly Identified Protein May Inhibit Hepatitis Virus. ScienceDaily. Retrieved August 4, 2015 from www.sciencedaily.com/releases/2005/04/050419105339.htm
American Society For Microbiology. "Newly Identified Protein May Inhibit Hepatitis Virus." ScienceDaily. www.sciencedaily.com/releases/2005/04/050419105339.htm (accessed August 4, 2015).

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