Featured Research

from universities, journals, and other organizations

Mayo Clinic Researchers Use Pharmacogenetic Test Prior To Chemotherapy To Reduce Toxic Side Effects

Date:
May 16, 2005
Source:
Mayo Clinic
Summary:
Mayo Clinic researchers report that using a genetic screening blood test prior to the start of chemotherapy can decrease the toxicity of a three-drug chemotherapy regimen, thus helping patients tolerate markedly different amounts of each of the three drugs.

ROCHESTER, Minn. -- Mayo Clinic researchers report that using a genetic screening blood test prior to the start of chemotherapy can decrease the toxicity of a three-drug chemotherapy regimen, thus helping patients tolerate markedly different amounts of each of the three drugs.

Related Articles


Mayo researchers will present these findings at the 2005 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Fla. The three drugs involved in their investigation are irinotecan, oxaliplatin and capecitabine, and each is individually approved by the Food and Drug Administration (FDA) for the treatment of cancer.

"By using the genetic test prior to the start of chemotherapy, we demonstrated that you can put these drugs together safely," says Mayo Clinic medical oncologist Matthew Goetz, M.D., the study's lead investigator. Co-investigator and oncology researcher Matthew Ames, Ph.D., adds, "We defined different patient populations based on a specific genetic variant to provide a better understanding of how this three-drug regimen will affect individual patients."

Significance of the Mayo Clinic Research

Of the three drugs, irinotecan can be particularly toxic for some patients. Despite the antitumor benefit of each drug, researchers have had difficulty putting the drugs together because the toxicity can be lethal.

The genetic test detects a change in the DNA of a gene that encodes for a protein involved in the metabolism of irinotecan. The test gives scientists advance knowledge of the individual risk for toxicity from irinotecan. As a result, scientists are able to tailor this chemotherapy regimen to the individual, thus reducing toxicity. This kind of customized dosing approach based on a person's genetic makeup is known as "pharmacogenomics" and is the newest frontier of 21st century medicine.

"In the past, a physician knew that the genetic test could predict a higher risk for irinotecan-related toxicity," says Dr. Goetz, "but no one knew what to do with this information with regard to dosing, both for irinotecan and drugs combined with irinotecan. Our study is the first to demonstrate that when you give these drugs in combination, a patient's individual genetic makeup affects the tolerable dose."

The Next Step

Having met the goal of using the genetic test to dose patients, Mayo Clinic researchers will test this combination therapy against specific cancers.

###

Collaboration and Support

In addition to Drs. Goetz and Ames, the Mayo Clinic research team included Stephanie Safgren; Joel Reid, Ph.D.; Sumithra Mandrekar, Ph.D.; Alfred Furth; Alex Adjei, M.D., Ph.D.; Axel Grothey, M.D.; Charles Erlichman, M.D.; Joseph Rubin, M.D.; and Mary Kuffel. Richard Goldberg, M.D., of the University of North Carolina, Chapel Hill, N.C., also collaborated on this study.

DISCLOSURE: This study was supported by grants from the National Cancer Institute (NCI).

To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Researchers Use Pharmacogenetic Test Prior To Chemotherapy To Reduce Toxic Side Effects." ScienceDaily. ScienceDaily, 16 May 2005. <www.sciencedaily.com/releases/2005/05/050516055118.htm>.
Mayo Clinic. (2005, May 16). Mayo Clinic Researchers Use Pharmacogenetic Test Prior To Chemotherapy To Reduce Toxic Side Effects. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2005/05/050516055118.htm
Mayo Clinic. "Mayo Clinic Researchers Use Pharmacogenetic Test Prior To Chemotherapy To Reduce Toxic Side Effects." ScienceDaily. www.sciencedaily.com/releases/2005/05/050516055118.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins