Featured Research

from universities, journals, and other organizations

Researchers Find First Gene For Inherited Testicular Cancer In Mice

Date:
May 18, 2005
Source:
Case Western Reserve University
Summary:
In this week's journal Nature, researchers report finding the first gene responsible for inherited susceptibility of testicular cancer in mice. The Ter mutation occurs in a gene called dead end, which is involved in normal testicular development and which may play a role in inherited forms of a testicular cancer occurring in infants. The mutation causes a huge increase in testicular cancer incidence, from 5 percent to 94 percent.

In this week's journal Nature, researchers report finding the first gene responsible for inherited susceptibility of testicular cancer in mice. The Ter mutation occurs in a gene called dead end, which is involved in normal testicular development and which may play a role in inherited forms of a testicular cancer occurring in infants.

The mutation causes a huge increase in testicular cancer incidence, from 5 percent to 94 percent. Although this dramatic rise was described in a mouse strain more than 30 years ago, it has taken until now for the identity of the gene itself to be discovered.

These results suggest that the Ter mutation may adversely affect essential aspects of primordial germ cell biology, and the authors explain that the work will have important implications for understanding of the genetic control of testicular germ cell tumors.

"Dead end is the earliest acting genetic defect that leads to these tumors," said Joseph Nadeau, Ph.D., a co-senior author of the paper and the Jewell Professor and Chair of Genetics at the Case Western Reserve University School of Medicine. "Interestingly, this defect causes these mice to develop tumors during fetal development. The mutation in the dead end gene increases susceptibility nearly 20 fold and is therefore one of the most potent inherited cancer genes," he said.

The researchers say that the gene appears to be involved in controlling RNA editing, which is a poorly understood process to change the RNA sequence in specific ways to build proteins.

"For the first time, we know the identity of one of the genes that controls inherited susceptibility. This gene and other functionally related genes might be used to diagnose at-risk individuals for more careful monitoring. And perhaps by understanding the role of RNA editing in the biology of the cancer stem cells we can develop improved therapeutics to treat and perhaps prevent these cancers,"said Nadeau.

"Our discovery also has implications for studies of stem cell biology. Many forms of testicular cancer, including the pediatric forms, originate from perhaps the most important stem cell, the primordial germ cell," he said.

Angabin Matin, Ph.D., the paper's other senior co-author and an assistant professor in the Department of Molecular Genetics at the University of Texas, MD Anderson Cancer Center in Houston, said, "Germ cell tumors arise from primordial germ cells, which become transformed into embryonal carcinoma cells (EC cells) before giving rise to the tumors. EC cells were observed to be pluripotent and have stem cell like properties in that they can be made to differentiate into many cell and tissue types and they have been used for this purpose before the derivation of embryonic stem cells (ES cells) directly from mouse embryos. The knowledge that loss of dead end allows EC cells to develop will provide clues as to how and why pluripotent cells arise."

Testicular cancer is the most common type of cancer among males between 15 to 30 years of age, and its incidence is increasing in western countries.

The researchers named the mutation Ter for teratoma, a form of testicular cancer.

###

The research institutions involved with the study are Case Western Reserve University's Department of Genetics, the Case Comprehensive Cancer Center, Duke University, University of Texas MD Anderson Cancer Center, NCI Frederick, and the Lawrence Berkeley National Laboratory.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Researchers Find First Gene For Inherited Testicular Cancer In Mice." ScienceDaily. ScienceDaily, 18 May 2005. <www.sciencedaily.com/releases/2005/05/050518175603.htm>.
Case Western Reserve University. (2005, May 18). Researchers Find First Gene For Inherited Testicular Cancer In Mice. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2005/05/050518175603.htm
Case Western Reserve University. "Researchers Find First Gene For Inherited Testicular Cancer In Mice." ScienceDaily. www.sciencedaily.com/releases/2005/05/050518175603.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins