ScienceDaily (Aug. 31, 2005) — Advances in the molecular modeling and simulation of complex biological systems are enabling researchers to study how certain microbial systems may play an important role in the remediation of contaminated soils. One target is Pseudomonas aeruginosa, a common microbe in sediments and the subsurface. This bacterium is also an important opportunistic pathogen that can cause fatal infections in people with a weakened immune systems.

T.P. Straatsma is leading a team of researchers modeling the lipopolysaccharide outer membrane of P. aeruginosa to learn how the membrane responds to its environment. This research is addressing the question of how this microbe adsorbs to mineral surfaces and what the mechanism is for the uptake and reduction of heavy metals. This has signifi cant implications for bioremediation applications if these metals are radioactive and are reduced to insoluble form to prevent further spreading of the contamination.

In another project, the team also is addressing the health related issues concerning this microbe. Again focusing on the outer membrane, Straatsma and his coworkers are studying the role of a range of proteins embedded in the membrane, as well as the mechanism of action of certain antibiotics that are effective in treating P. aeruginosa infections that plague cystic fi brosis patients, burn victims and patients with compromised immune systems.

Pacific Northwest National Laboratory researcher Tjerk Straatsma will be presenting his results at 2:10 p.m., Monday, Aug. 29.

Computer model of the outer membrane of the bacterium Pseudomonas aeruginosa, used by Pacific Northwest National Laboratory researchers to explore the interaction with antibiotics and the transport of molecules through membrane proteins. (Image courtesy of DOE/Pacific Northwest National Laboratory)

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