Featured Research

from universities, journals, and other organizations

Researcher Identifies New Way Of Combating Viral Diseases

Date:
September 13, 2005
Source:
University of Georgia
Summary:
Four seemingly unrelated viral diseases may some day be defeated by a single treatment, according to a recent collaborative study involving researchers at the University of Georgia's College of Veterinary Medicine. Their study focuses on viruses responsible for HIV, measles, Ebola and Marburg and includes investigators from Vanderbilt University Medical Center and the Centers for Disease Control and Prevention. The study is being funded by a grant from the Hudson-Alpha Institute for Biotechnology.

Four seemingly unrelated viral diseases may some day be defeated by asingle treatment, according to a recent collaborative study involvingresearchers at the University of Georgia's College of VeterinaryMedicine.

Their study focuses on viruses responsible for HIV, measles, Ebolaand Marburg and includes investigators from Vanderbilt UniversityMedical Center and the Centers for Disease Control and Prevention. Thestudy is being funded by a grant from the Hudson-Alpha Institute forBiotechnology.

In the September issue of the Journal of Virology, ThomasHodge, research professor of infectious diseases at the veterinarycollege, and his colleagues report that blocking a protein that helpstransport viruses out of a cell keeps these four viruses fromreproducing and infecting other cells.

Most antiviral therapies target the virus itself, but virusesare quick to adapt to the body's attempts to disable them, Hodgeexplained. They can mutate rapidly and develop resistance to almost anyantiviral compound. By focusing on the host cell while most scientistsconcentrate on the virus, Hodge and his colleagues hope to identify newways to combat viral diseases.

The researchers identified a cellular protein called Rab9 -- a factor required for viruses to reproduce in a cell.Disrupting Rab9 prevented the replication of four different viruses -- Marburg, Ebola, HIV-1, and measles viruses.

"We believe that interfering with the Rab9 pathway interfereswith the ability of the viruses to exit the cell, thereby dramaticallydecreasing the ability of the virus to spread rapidly and produceinfection," Hodge said.

Because these viruses depend heavily on this exit pathway, theyprobably would not be able to find another route out of the cell. Thissuggests that Rab9 and other components of this exit pathway might beattractive targets for antiviral therapies for a variety of viruses.

Blocking Rab9 may have significant side effects, but there arepeople who live without Rab9, Hodge explained. Although they havemetabolic problems, they are generally able to control their conditionwith diet and medication.Temporarily blocking the Rab9 pathway would be unlikely to harm thebody, Hodge added, because human cells tend to have backup systems thatcan compensate.


Story Source:

The above story is based on materials provided by University of Georgia. Note: Materials may be edited for content and length.


Cite This Page:

University of Georgia. "Researcher Identifies New Way Of Combating Viral Diseases." ScienceDaily. ScienceDaily, 13 September 2005. <www.sciencedaily.com/releases/2005/09/050912123953.htm>.
University of Georgia. (2005, September 13). Researcher Identifies New Way Of Combating Viral Diseases. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2005/09/050912123953.htm
University of Georgia. "Researcher Identifies New Way Of Combating Viral Diseases." ScienceDaily. www.sciencedaily.com/releases/2005/09/050912123953.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins