Featured Research

from universities, journals, and other organizations

Myelin Suppresses Plasticity In The Mature Brain

Date:
September 30, 2005
Source:
Yale University
Summary:
Yale School of Medicine researchers report in Science this week genetic evidence for the hypothesis that myelination, or formation of a protective sheath around a nerve fiber, consolidates neural circuitry by suppressing plasticity in the mature brain.

New Haven, Conn.-Yale School of Medicine researchers report inScience this week genetic evidence for the hypothesis that myelination,or formation of a protective sheath around a nerve fiber, consolidatesneural circuitry by suppressing plasticity in the mature brain.

Related Articles


This finding has implications for research on restoring mobility topeople who have lost motor functions due to spinal cord injury,multiple sclerosis, Lou Gehrig's disease, and other central nervoussystem disorders.

"The failure of surviving neurons to reestablish functionalconnection is most obvious after spinal cord injury, but limited nervecell regeneration and plasticity is central to a range of neurologicaldisorders, including stroke, head trauma, multiple sclerosis, andneurodegenerative disease," said senior author Stephen Strittmatter,professor in the Departments of Neurology and Neurobiology. "Recoveryof motor function after serious damage to the mature brain isfacilitated by structural and synaptic plasticity."

Strittmatter's laboratory studies how myelin in the centralnervous system physically limits axonal growth and regeneration aftertraumatic and ischemic injury, when blood supply is cut off. Aphysiological role for the myelin inhibitor pathway has not beendefined.

Blocking vision in one eye normally alters ocular dominance inthe cortex of the brain only during a critical developmental period, or20 to 32 days postnatal in mice. Strittmatter's lab, working incollaboration with Nigel Daw, M.D., professor of ophthalmology andneuroscience, and his group, found that mutations in the Nogo-66receptor (NgR) affect plasticity of ocular dominance. In mice withaltered NgR, plasticity during the critical period is normal, but itcontinues abnormally so that ocular dominance later in development issimilar to the plasticity of juvenile stages.

###

Science (September 30, 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Myelin Suppresses Plasticity In The Mature Brain." ScienceDaily. ScienceDaily, 30 September 2005. <www.sciencedaily.com/releases/2005/09/050930081337.htm>.
Yale University. (2005, September 30). Myelin Suppresses Plasticity In The Mature Brain. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2005/09/050930081337.htm
Yale University. "Myelin Suppresses Plasticity In The Mature Brain." ScienceDaily. www.sciencedaily.com/releases/2005/09/050930081337.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins