Featured Research

from universities, journals, and other organizations

Can Pomegranates Prevent Prostate Cancer? A New Study Offers Promise

Date:
October 2, 2005
Source:
University of Wisconsin-Madison
Summary:
The juice of the pomegranate, say researchers at University of Wisconsin Medical School, shows major promise to combat prostate cancer - the most common invasive cancer and the second-leading cause of cancer death in American men.

MADISON - The juice of the pomegranate, say researchers at Universityof Wisconsin Medical School, shows major promise to combat prostatecancer - the most common invasive cancer and the second-leading causeof cancer death in American men.

With more than 230,000 new cases of prostate cancer expected to bediagnosed this year alone in the U.S. and the outlook poor for patientswith metastatic disease, researchers are looking for new strategies tocombat the disease. Earlier research at Wisconsin and elsewhere hasshown that the pomegranate, a fruit native to the Middle East, is richin anti-oxidant and anti-inflammatory activity and is effective againsttumors in mouse skin. In fact, pomegranate juice has higheranti-oxidant activity than do red wine and green tea, both of whichappear promising as anti-cancer agents.

The UW research team aimed to find out if the extract frompomegranates would not only kill existing cancer, but help preventcancer from starting or progressing. Using human prostate cancer cells,the team first evaluated the fruit extract's effect, at various doses,on those cells cultured in laboratory dishes. They found a"dose-dependent" effect - in other words, the higher the dose ofpomegranate extract the cells received, the more cells died.

The research team then progressed to tests in mice that hadbeen injected with prostate cancer cells from humans and developedmalignancies. The 24 mice were randomly divided into three groups. Thecontrol group received normal drinking water, while the animals in thesecond and third groups had their drinking water supplemented with .1percent and .2 percent pomegranate extract respectively. The doses forthe mice were chosen to parallel how much pomegranate juice a typicalhealthy human might be willing to eat or drink daily.

The results were dramatic: the mice receiving the higherconcentration of pomegranate extract showed significant slowing oftheir cancer progression and a decrease in the levels ofprostate-specific antigen (PSA), a marker used to indicate the presenceof prostate cancer in humans. The animals that received only water hadtumors that grew much faster than those in the animals treated withpomegranate extract.

"Our study - while early -- adds to growing evidence thatpomegranates contain very powerful agents against cancer, particularlyprostate cancer," says lead author Dr. Hasan Mukhtar, professor ofdermatology in the UW Medical School. "There is good reason now to testthis fruit in humans - both for cancer prevention and for treatment."

The next step in the evaluation of pomegranates for cancerprevention and treatment is to conduct tests in humans, according toMukhtar.

###

The other members of the research team are Arshi Malik, FarrukhAfaq, Vaquar Adhami, Deeba Syed and Sami Sarfaraz, all researchscientists in the department of dermatology. The Wisconsin research wasfunded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University of Wisconsin-Madison. "Can Pomegranates Prevent Prostate Cancer? A New Study Offers Promise." ScienceDaily. ScienceDaily, 2 October 2005. <www.sciencedaily.com/releases/2005/10/051002120002.htm>.
University of Wisconsin-Madison. (2005, October 2). Can Pomegranates Prevent Prostate Cancer? A New Study Offers Promise. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2005/10/051002120002.htm
University of Wisconsin-Madison. "Can Pomegranates Prevent Prostate Cancer? A New Study Offers Promise." ScienceDaily. www.sciencedaily.com/releases/2005/10/051002120002.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins