Featured Research

from universities, journals, and other organizations

Flavonoids May Inhibit Prostate Cancer

Date:
October 21, 2005
Source:
Case Western Reserve University
Summary:
Researchers orally fed the flavonoid apigenin to mice two weeks before implanting a prostate tumor, then continuing the feedings for eight weeks. In a second protocol, apigenin was fed to mice two weeks after tumor implantation. The first protocol mimicked prevention regimens, while the second followed therapeutic regimens for cancer. In both cases, the apigenin slowed tumor growth and did not appear to cause any adverse side effects.

Eating a diet rich in fruits and vegetables could be a good defense against prostate cancer, according to a Case Western Reserve University study published in the October online issue of the Federation of American Societies for Experimental Biology Journal.

Previous studies have suggested that increased intake of flavonoids which are common in fruits and vegetables may be associated with a reduced risk of prostate cancer, according to Sanjay Gupta, Ph.D., an assistant professor in the Case School of Medicine Department of Urology. Apigenin is a plant flavonoid commonly found in fruits and vegetables, as well as herbs, including chamomile, lemon balm, perilla and parsley.

"Flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health, and have reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities," Gupta said. "Apigenin has been shown to lower inflammation and oxidative stress, and exerts growth inhibitory effects on cancer cells."

In the study, Gupta and his team orally fed apigenin to mice two weeks before implanting a prostate tumor, then continuing the feedings for eight weeks. In a second protocol, apigenin was fed to mice two weeks after tumor implantation.

The first protocol mimicked prevention regimens, while the second followed therapeutic regimens for cancer.

In both cases, the apigenin slowed tumor growth and did not appear to cause any adverse side effects such as weight gain or changes in diet, which is common in patients who undergo chemotherapy treatments.

Apigenin also resulted in a decrease in IGF-1 (insulin-like growth factor) levels, which are associated with an increased risk of breast, prostate, colorectal and lung cancers, as well as a significant increase in IGFBP-3 (insulin-like growth factor binding protein) levels, which is associated with a decreased risk for these same cancers. The effect impacts the survival of prostate cancer by triggering cell self-destruction.

"Apigenin may prove useful in the prevention and therapy of prostate cancer by shutting off the IGF signaling that leads to prostate cancer cell growth and/or development," Gupta said.

"Our findings suggest that apigenin could be developed as a promising agent against prostate cancer," Gupta said. "The next step is to evaluate apigenin action on other molecular pathways which have relevance to prostate cancer."

Gupta's colleagues contributing to the study included Sanjeev Shukla, Ph.D.; Gregory T. MacLennan, M.D.; Pingfu Fu, Ph.D.; Martin I. Resnick, M.D.; from Case Western Reserve University and University Hospitals of Cleveland, and Anil Mishra, Ph.D. from University of Pittsburgh.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Flavonoids May Inhibit Prostate Cancer." ScienceDaily. ScienceDaily, 21 October 2005. <www.sciencedaily.com/releases/2005/10/051021021503.htm>.
Case Western Reserve University. (2005, October 21). Flavonoids May Inhibit Prostate Cancer. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2005/10/051021021503.htm
Case Western Reserve University. "Flavonoids May Inhibit Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/10/051021021503.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins