Featured Research

from universities, journals, and other organizations

New Link Between Gum And Cardiovascular Diseases

Date:
December 4, 2005
Source:
Virginia Commonwealth University
Summary:
Virginia Commonwealth University researchers have found that changes in the plasma lipoprotein profile of patients with severe periodontitis -- a condition characterized by chronic infection and inflammation of the gums - may contribute to these patients' elevated risk for heart disease and stroke.

Virginia Commonwealth University researchers have found that changes in the plasma lipoprotein profile of patients with severe periodontitis – a condition characterized by chronic infection and inflammation of the gums - may contribute to these patients’ elevated risk for heart disease and stroke.

Related Articles


The findings suggest that it may be beneficial to test periodontitis patients for changes in their plasma lipoprotein profiles, so that available medication can be taken if necessary.

In the December issue of the Journal of Lipid Research, researchers found that patients with generalized aggressive periodontitis generally had elevated plasma levels of a particularly bad subclass of the low density lipoprotein (LDL) called small-dense LDL.

“Previous research has shown that people who have predominantly small-dense LDL in their blood are at a three- to six-fold increased risk of heart disease and stroke”, said lead author Rik van Antwerpen, Ph.D., an assistant professor of biochemistry at VCU. “A person may have predominantly small-dense LDL without having alarmingly high blood levels of cholesterol. Therefore, unhealthy levels of small-dense LDL are not always detected in regular cholesterol tests.”

According to the study, a second factor influencing the cardiovascular risk of patients with severe periodontitis may be platelet activating factor acetylhydrolase (PAF-AH), an enzyme that is associated with small-dense LDL. PAF-AH is able to break down some of the inflammatory, atherogenic components of LDL. Van Antwerpen said that the enzyme may lower the atherogenic effects of LDL, and that the observed decrease of LDL-associated PAF-AH activity in patients with severe periodontitis may increase the cardiovascular risk of these patients.

“Our results indicate that these differences may in part be responsible for the enhanced plaque build up in the arteries of patients with severe periodontitis,” said van Antwerpen.

In this study, a limited number of participants were enrolled – 12 patients with generalized aggressive periodontitis and 12 control subjects without periodontal disease. Currently, van Antwerpen and his colleagues are evaluating a greater number of patients with varying degrees of periodontal infection and inflammation as they work toward establishing testing guidelines for periodontitis patients.

This research was supported by grants from the National Institutes of Health.

Van Antwerpen collaborated with Harvey A. Schenkein, Ph.D., Director of the Clinical Research Center for Periodontal Diseases, and chair of the Department of Periodontics, VCU School of Dentistry; Suzanne E. Barbour, Ph.D., associate professor in the Department of Biochemistry, VCU School of Medicine; John G. Tew, Ph.D., professor in the Department of Microbiology and Immunology, VCU School of Medicine. Experiments were carried out by Miguel Rufail, a graduate student in the VCU Department of Biochemistry.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Commonwealth University. "New Link Between Gum And Cardiovascular Diseases." ScienceDaily. ScienceDaily, 4 December 2005. <www.sciencedaily.com/releases/2005/12/051204103537.htm>.
Virginia Commonwealth University. (2005, December 4). New Link Between Gum And Cardiovascular Diseases. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2005/12/051204103537.htm
Virginia Commonwealth University. "New Link Between Gum And Cardiovascular Diseases." ScienceDaily. www.sciencedaily.com/releases/2005/12/051204103537.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins