Featured Research

from universities, journals, and other organizations

UCLA Paper Examines How One Disease May Prevent Another

Date:
January 6, 2006
Source:
University of California - Los Angeles
Summary:
This paper reviews examples from medical history of ways that one disease prevents another. The findings suggest that genetic, infectious and metabolic influences should be considered when looking for new treatments, particularly in regard to HIV/AIDS.

The knowledge that one disease may prevent the onset of another is not new. For example, the discovery that cowpox vaccines can prevent smallpox dates back to 1798.

Related Articles


Dr. E. Richard Stiehm, a professor of pediatrics at the Mattel Children's Hospital at UCLA, researched examples throughout medical history of ways that one disease prevents another.

His findings suggest that genetic, infectious and metabolic influences should be considered when looking for treatments, particularly in regard to HIV/AIDS.

"Clinical observations of disease-versus-disease interactions have led to an understanding of the mechanisms of several diseases," Stiehm said. "In turn, these observations have led to the development of vaccines, therapeutic antibodies, medications and special diets."

Detailed in the January 2006 issue of Pediatrics, the official peer-reviewed journal of the American Academy of Pediatrics, Stiehm's research illustrated 12 disease pairs, reviewed their therapeutic implications and suggested additional applications.

A few of the pairings that Stiehm described include:

Sickle cell disease and malaria. In 1948, British biologist J.B. Haldane proposed that malaria was an evolutionary force for selecting malaria-resistant genes. He suggested that those carrying the gene for sickle cell anemia were better able to survive in malaria-infected areas.

Leprosy patients have severe immune defects and cutaneous anergy — an inability to respond to skin testing. They hardly ever get psoriasis, a skin disorder. Starvation was used since biblical times for the treatment of seizures, which were believed to be demons. A 1924 discovery showed that a diet rich in fat and low in carbohydrates mimicked starvation by causing ketonemia and also controlled seizures. The ketogenic diet is still used today for cases of epilepsy resistant to medication.

During the 1944 winter of starvation when bread supplies to the children's hospital were interrupted at The Hague, young patients with celiac disease, a digestive disease that damages the small intestine and interferes with absorption of nutrients from food, thrived on their "non-bread" diet. Wheat was discovered to be the culprit. Other diseases that benefit from severe caloric or protein restriction include kidney failure, type-II diabetes, inflammatory bowel disease and morbid obesity.

Overall, Stiehm proposed that new evidence can be found for using certain viruses to treat diseases such as HIV, which do not respond to other medications.

"There have been several studies indicating that HIV patients co-infected with a virus related to Hepatitis C, called GB virus C, have less severe HIV disease and improved survival," Stiehm said.

Stiehm got the idea for his historical review from cases he saw while a pediatric resident at Babies Hospital in New York City. One case was a kidney disease patient with nephrosis who was unresponsive to medications but went into remission after contracting measles. The other, a cystic fibrosis (CF) patient who needed to be admitted to the hospital, but there were no rooms available. Stiehm's supervisor, a CF specialist, told him, "put him in the room with the tuberculosis patient — CF patients never get tuberculosis." Subsequent studies have confirmed this observation.

Mattel Children's Hospital at UCLA is a 120-bed "hospital within a hospital" located at UCLA Medical Center in Westwood. The hospital offers a full spectrum of primary and specialized medical care for infants, children and adolescents. The mission of Mattel Children's Hospital at UCLA is to provide state-of-the-art treatment for children in a compassionate atmosphere, as well as to improve the understanding and treatment of pediatric diseases. For more information, visit http://www.mattel.ucla.edu/.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "UCLA Paper Examines How One Disease May Prevent Another." ScienceDaily. ScienceDaily, 6 January 2006. <www.sciencedaily.com/releases/2006/01/060106003230.htm>.
University of California - Los Angeles. (2006, January 6). UCLA Paper Examines How One Disease May Prevent Another. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2006/01/060106003230.htm
University of California - Los Angeles. "UCLA Paper Examines How One Disease May Prevent Another." ScienceDaily. www.sciencedaily.com/releases/2006/01/060106003230.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins