Featured Research

from universities, journals, and other organizations

Genetic Clues To Sodalis Deepens Knowledge Of Bacterial Diseases

Date:
January 10, 2006
Source:
Yale University
Summary:
By sequencing the genome of the symbiotic bacterium Sodalis, which lives off the major disease-transmitting insect, the tsetse fly, researchers at Yale School of Medicine have come a step closer to understanding how microbial pathogens cause disease.

The tsetse fly is one of many eukaryotes (animals) that live in association with symbiotic microbes or bacteria.
Credit: Image courtesy of Yale University

By sequencing the genome of the symbiotic bacterium Sodalis, which lives off the major disease-transmitting insect, the tsetse fly, researchers at Yale School of Medicine have come a step closer to understanding how microbial pathogens cause disease.

Led by Serap Aksoy, professor in the Department of Epidemiology and Public Health at Yale School of Medicine, the team was highly interested in Sodalis because of its close relation to human bacterial pathogens like E.Coli, Salmonella and Yersinia.

Published online December 15 in Genome Research, the study looked at the genome in Sodalis, the second of three kinds of bacteria known to aid the tsetse fly in feeding off the blood of its host. The tsetse fly is one of many eukaryotes (animals) that live in association with symbiotic microbes or bacteria. These animals depend on the microbes for vital nutrients they can't otherwise produce.

"We have been able to develop the first system to grow Sodalis in vitro in the laboratory," said Aksoy. "We were then able to genetically modify the symbiotic bacteria and put it back into the tsetse fly to manipulate host traits or functions. Information on the blueprint of this organism now gives us a better handle on this applied strategy."

When the team sequenced the bacterial genome, they found the hallmarks of an organism transitioning from a free-living state to a symbiotic state. "It's a relatively young association between the tsetse host and the bacterium," said Aksoy. "Surprisingly, Sodalis has many of the same features of pathogenic bacteria, although it is obviously a beneficial organism that poses no harm to the tsetse host. We can now investigate how these potentially pathogenic features function in a beneficial relationship. It has changed our view of host pathogen characteristics."

Aksoy and her team also found that the genome itself, in terms of physical structure and size, looks similar to free-living bacteria. As relationships become symbiotic--more and more dependent on the host--bacterial genomes usually begin to shrink, but in the case of Sodalis, it is the same size as the free-living bacteria. It has the largest number of pseudogenes, products with no function, of any bacteria to date, again indicating its recent transition to a symbiotic lifestyle.

"If we get rid of these symbiotic bacteria, the flies become sterile, so understanding what they provide to the flies is very important from a vector control point of view," Aksoy said. "The sequence will be extremely helpful and will expand functional studies. We have increased understanding of how Sodalis transitions from a free-living to a symbiotic state."

###

Other authors on the study included Hidehiro Toh, Brian L. Weiss, Sarah Perkin, Atsushi Yamashita, Kenshiro Oshima and Masahira Hattori.

Citation: Genome Research, Published online December 15, 2005
Print Publication: February 2006.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Genetic Clues To Sodalis Deepens Knowledge Of Bacterial Diseases." ScienceDaily. ScienceDaily, 10 January 2006. <www.sciencedaily.com/releases/2006/01/060110012927.htm>.
Yale University. (2006, January 10). Genetic Clues To Sodalis Deepens Knowledge Of Bacterial Diseases. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2006/01/060110012927.htm
Yale University. "Genetic Clues To Sodalis Deepens Knowledge Of Bacterial Diseases." ScienceDaily. www.sciencedaily.com/releases/2006/01/060110012927.htm (accessed October 22, 2014).

Share This



More Plants & Animals News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Reuters - US Online Video (Oct. 21, 2014) Police in Gary, Indiana are using cadaver dogs to search for more victims after a suspected serial killer confessed to killing at least seven women. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
White Lion Cubs Unveiled to the Public

White Lion Cubs Unveiled to the Public

Reuters - Light News Video Online (Oct. 21, 2014) Visitors to Belgrade zoo meet a pair of three-week-old lion cubs for the first time. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins