Featured Research

from universities, journals, and other organizations

Call Not To Use Certain Type Of Anti-viral Drugs For Influenza A Virus For 2006 Flu Season

Date:
February 14, 2006
Source:
JAMA and Archives Journals
Summary:
Recent, additional data show that the prevalence of adamantane-resistant influenza A viruses is high across the United States, according to a new study published online today by JAMA because of its public health importance. The study will be in the February 22 print issue of JAMA.

Recent, additional data show that the prevalence of adamantane-resistant influenza A viruses is high across the United States, according to a new study published online today by JAMA because of its public health importance. The study will be in the February 22 print issue of JAMA.

On Jan. 14, 2006, the Centers for Disease Control and Prevention (CDC) issued a Health Alert recommending that certain anti-viral drugs, specifically amantadine and rimantadine should not be used for treatment or prevention of influenza A infections in the United States for the remainder of the 2005 - 2006 influenza season. This recommendation was based on 120 influenza A viruses isolated from patients in 23 states.

Amantadine and rimantadine are in a class of drugs called adamantanes and have been used as a first-choice antiviral drug against community outbreaks of influenza A viruses for many years. According to the authors of the current JAMA study, rates of viruses resistant to these drugs have been increasing globally and rapid surveillance for the emergence and spread of resistant viruses is critical for the treatment of patients. The authors write that on average, influenza A viruses, a major cause of illness and death in the U.S., infect about 10 - 15 percent of the population annually. While vaccination is the primary strategy for preventing influenza infections, influenza antiviral drug therapy (such as amantadine and rimantadine) is effective for treating patients with the flu, especially in nursing homes and long term care facilities.

Rick A. Bright, Ph.D., and colleagues from the CDC, Atlanta, analyzed 209 influenza isolates collected from patients in 26 states from Oct. 1 through Dec. 31, 2005, and tested for drug resistance as part of ongoing surveillance. "Of the 209 A (H3N2) viruses screened, we found an alarmingly high adamantane resistance rate of 92 percent," the researchers report. "These viruses were isolated from patients residing in 26 states, representing all regions of the United States. This rate was much higher than the rate found among viruses collected within the United States during previous influenza seasons."

"Our results highlight the importance of continued surveillance for the emergence and transmission of influenza viruses resistant to antiviral drugs. They serve as a warning to the medical community of the speed at which resistant influenza viruses can become predominant circulating strains and spread throughout a continent," the authors conclude.

###

(JAMA. 2006. Available pre-embargo to the media at www.jamamedia.org.)

Editorial: Adamantane Resistance in Influenza A
In an accompanying editorial, David M. Weinstock, M.D., and Gianna Zuccotti, M.D., M.P.H., from Memorial Sloan-Kettering Cancer Center, New York, write "the global burden of influenza infection is staggering. In a typical year, approximately 20 percent of the world's population is infected and more than a half million individuals die of influenza-associated complications."

"The report by Bright and colleagues is a clarion call for action from the medical community. Physicians and other health care professionals must (1) educate patients and communities; (2) organize an international response through governmental and nongovernmental organizations; (3) advocate against the release of over-the-counter antiviral drugs, either directly by major drug companies or through licensing agreements with generic manufacturers; and (4) recognize the powerful influences that affect prescribing practices before assigning culpability to those who have inappropriately used adamantanes."

In conclusion, they write: "The response must be global and immediate. If successful, there is some evidence that the prevalence of resistance not only might stabilize, but actually decrease."

(JAMA. 2006. Available pre-embargo to the media at www.jamamedia.org.)


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Call Not To Use Certain Type Of Anti-viral Drugs For Influenza A Virus For 2006 Flu Season." ScienceDaily. ScienceDaily, 14 February 2006. <www.sciencedaily.com/releases/2006/02/060213183006.htm>.
JAMA and Archives Journals. (2006, February 14). Call Not To Use Certain Type Of Anti-viral Drugs For Influenza A Virus For 2006 Flu Season. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2006/02/060213183006.htm
JAMA and Archives Journals. "Call Not To Use Certain Type Of Anti-viral Drugs For Influenza A Virus For 2006 Flu Season." ScienceDaily. www.sciencedaily.com/releases/2006/02/060213183006.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins