Featured Research

from universities, journals, and other organizations

Biologists Develop Genome-Wide Map Of MiRNA-mRNA Interactions

Date:
March 9, 2006
Source:
New York University
Summary:
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

Related Articles


MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. Parts of the predicted map were confirmed through the development of a novel in vivo method that asked whether the 3' UTR part of mRNAs was driving regulation during development in a living organism. Their research appears in the most recent issue of Current Biology.

In mapping miRNA targets, the research team examined the function of the genome of C. elegans, the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. Using PicTar, an algorithm developed at NYU, the researchers predicted miRNA functions of C. elegans genes. The researchers found that one-third of C. elegans miRNAs target gene sets have related functions. That is, it appears that miRNAs can control groups of genes that work in a specific biological process. At least 10 percent of C. elegans genes are predicted miRNA targets.

To test the computational predictions, the NYU team developed a new in vivo analysis system comparing the expression of a reporter, green fluorescent protein (GFP) carrying target 3' UTRs with controls, that did not carry the target 3'UTRs. The laboratory results confirmed the role of specific 3' UTRs in suppressing gene expression even more widely than predicted by the computational analysis, suggesting that 3' UTRs contain a largely unexplored universe for gene regulation.

The thousands of genome-wide miRNA target predictions for nematodes, or roundworms, humans, and flies are available from the PicTar website (pictar.bio.nyu.edu) and are linked to a new graphical network-browsing tool developed in the NYU Center for Comparative Functional Genomics. This allows for exploration of miRNA target predictions in the context of various functional genomic data resources (gnetbrowse.org).

The research was supported by grants from the National Science Foundation and the National Institutes of Health.


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Cite This Page:

New York University. "Biologists Develop Genome-Wide Map Of MiRNA-mRNA Interactions." ScienceDaily. ScienceDaily, 9 March 2006. <www.sciencedaily.com/releases/2006/03/060308213357.htm>.
New York University. (2006, March 9). Biologists Develop Genome-Wide Map Of MiRNA-mRNA Interactions. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2006/03/060308213357.htm
New York University. "Biologists Develop Genome-Wide Map Of MiRNA-mRNA Interactions." ScienceDaily. www.sciencedaily.com/releases/2006/03/060308213357.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Computers & Math News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) — More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Sundance Films Tap Into Virtual Reality

Sundance Films Tap Into Virtual Reality

Newsy (Jan. 25, 2015) — Virtual reality headsets offer more experiences for viewers and filmmakers at the Sundance Film Festival. Video provided by Newsy
Powered by NewsLook.com
No, A Google Exec Did Not Predict An Internet Apocalypse

No, A Google Exec Did Not Predict An Internet Apocalypse

Newsy (Jan. 24, 2015) — Earlier this week, a Google exec made headlines for saying "the Internet will disappear," but that doesn&apos;t quite mean what it sounds like. Video provided by Newsy
Powered by NewsLook.com
Tim Cook Made 8 Times Less Than Another Apple Exec In 2014

Tim Cook Made 8 Times Less Than Another Apple Exec In 2014

Newsy (Jan. 23, 2015) — Tim Cook&apos;s total compensation more than doubled in 2014 to $9.2 million, but his pay was still less than four other Apple executives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins