Featured Research

from universities, journals, and other organizations

Researchers Identify Gene Depth Protects Against Kidney Stones

Date:
March 14, 2006
Source:
Yale University
Summary:
Scientists have identified a gene whose function protects the body against kidney stones. The research identifies a transporter, encoded by the gene, as a potential target for drugs to boost oxalate secretion in the gut and help prevent kidney stones.

Yale School of Medicine researchers report in Nature Genetics this week that they have identified a gene whose function protects the body against kidney stones.

The research identifies a transporter, encoded by the gene, as a potential target for drugs to boost oxalate secretion in the gut and help prevent kidney stones, said Peter Aronson, M.D., professor of internal medicine and physiology and senior author of the study.

The most common type of kidney stones are composed of calcium oxalate. The transporter, known as SLC26A6, normally secretes oxalate into the intestine and prevents absorption of too much of the oxalate from the diet.

"When this gene is knocked out in the mouse, more oxalate from the diet is absorbed, the plasma level of oxalate is increased, more oxalate is excreted in the urine by the kidney, and kidney stones are formed," Aronson said.

In addition to pinpointing a potential drug target, he said the research raises the possibility that abnormal expression or regulation of the anion transporter encoded by the gene could cause kidney stones in humans, although this has not yet been tested directly.

Co-authors include first author Zhirong Jiang, M.D., John Asplin, M.D., Andrew Evan, Vazhaikkurichi Rajendran, Heino Velazquez, Timothy Nottoli, and Henry Binder, M.D.

The study was supported by grants from the National Institute of Diabetes & Digestive & Kidney Diseases.

Nature Genetics (DOI)10.1038/Ng1762: (Published online March 12, 2006)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Researchers Identify Gene Depth Protects Against Kidney Stones." ScienceDaily. ScienceDaily, 14 March 2006. <www.sciencedaily.com/releases/2006/03/060313230759.htm>.
Yale University. (2006, March 14). Researchers Identify Gene Depth Protects Against Kidney Stones. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2006/03/060313230759.htm
Yale University. "Researchers Identify Gene Depth Protects Against Kidney Stones." ScienceDaily. www.sciencedaily.com/releases/2006/03/060313230759.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins