Featured Research

from universities, journals, and other organizations

More Evidence Of Cancer Fighting Benefit From Nutrients In Certain Vegetables

Date:
April 6, 2006
Source:
University of Pittsburgh Medical Center
Summary:
Studies continue to support the premise that dietary intake of cruciferous vegetables may be protective against the risk of various types of cancer. The anti-cancer effects of cruciferous vegetables are attributed to phytochemicals called organic isothiocyanates (ITCs). This study found that an ITC called phenethyl-ITC (PEITC) was highly effective in retarding the growth of human prostate cancer in mice, suggesting its potential as a chemotherapeutic agent to delay the onset or progression of prostate cancer.

Chemicals in cruciferous vegetables, such as broccoli, watercress, cabbage and cauliflower, appear to stop human prostate cancer cells from growing in mice by affecting the expression of proteins, says a University of Pittsburgh Cancer Institute study, abstract number 5601, being presented today at the annual meeting of the American Association for Cancer Research, at the Washington Convention Center in Washington, D.C.

Related Articles


"The contribution of diet and nutrition to cancer risk, prevention and treatment have been a major focus of research in recent years because certain nutrients in vegetables and dietary agents appear to protect the body against diseases such as cancer," said Shivendra Singh, Ph.D., lead investigator and professor of pharmacology and urology at the University of Pittsburgh School of Medicine. "From epidemiologic data, we know that increased consumption of vegetables reduces the risk for certain types of cancer, but now we are beginning to understand the mechanisms by which certain edible vegetables like broccoli help our bodies fight cancer and other diseases."

Dr. Singh's study is based on phytochemicals found in several cruciferous vegetables called isothiocyanates (ITCs), which are generated when vegetables are either cut or chewed. His laboratory has found that phenethyl-ITC, or PEITC, is highly effective in suppressing the growth of human prostate cancer cells at concentrations achievable through dietary intake of cruciferous vegetables.

In seeking to further define the mechanisms by which PEITC induces apoptosis, or programmed cell death, mice were grafted with human prostate tumors and orally administered a small amount of PEITC daily. After 31 days of treatment, the average tumor volume in the control group that did not receive PEITC was 1.9 times higher than that of the treatment group. In addition, a pro-apoptotic protein called Bax appeared to play a role in bringing about apoptosis by PEITC.

"Our next step is to design clinical trials to determine the efficacy of PEITC for prostate cancer prevention in men," said Dr. Singh.

The study was supported by a grant from the National Cancer Institute. Co-investigators include Stanley W. Marynowski, Jr., Dong Xiao, Ph.D., Karen L. Lew, Yan Zeng, Rajiv Dhir, M.D., and Hui Xiao, Ph.D., all with the University of Pittsburgh Cancer Institute.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "More Evidence Of Cancer Fighting Benefit From Nutrients In Certain Vegetables." ScienceDaily. ScienceDaily, 6 April 2006. <www.sciencedaily.com/releases/2006/04/060405235119.htm>.
University of Pittsburgh Medical Center. (2006, April 6). More Evidence Of Cancer Fighting Benefit From Nutrients In Certain Vegetables. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2006/04/060405235119.htm
University of Pittsburgh Medical Center. "More Evidence Of Cancer Fighting Benefit From Nutrients In Certain Vegetables." ScienceDaily. www.sciencedaily.com/releases/2006/04/060405235119.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins