Featured Research

from universities, journals, and other organizations

Viral Genomic Material Remains In The Human Body Long After Infection

Date:
May 7, 2006
Source:
University of Helsinki
Summary:
The researchers at the University of Helsinki, Finland, and the University Hospital of Bonn, Germany, have coined the novel term "Bioportfolio" to describe viral genomic material remaining in the human body after infection. Using human erythrovirus as the example, the authors have demonstrated that viral genomic material persisting in the human body yields valuable information on viral phylogeny and on molecular epidemiology of infection.

The researchers at the University of Helsinki, Finland, and University Hospital of Bonn, Germany, have coined the novel term "Bioportfolio" to describe viral genomic material remaining in the human body after infection. Using human erythrovirus as the example, the authors have demonstrated that viral genomic material persisting in the human body yields valuable information on viral phylogeny and on molecular epidemiology of infection.

Although these results are of greatest interest to the relatively small group interested in erythrovirus (parvovirus) research, the ideas discussed are of wider interest because they explore in an imaginative way some fundamental biological events occurring during and after infection.

The research group lead by professor Klaus Hedman at the University of Helsinki have investigated by qualitative and quantitative molecular assays a large number of human tissue samples (birth-year range 1913-2000) and patient sera from the past two decades, for genomic DNA of new and previously known human erythrovirus types. They disclosed in human tissues erythrovirus genome persistence, which is ubiquitous and life-long, and represents a new source of information of our past -- which they termed the Bioportfolio.

In the Bioportfolio the researchers observed that in Central and Northern Europe the newly found erythrovirus type 2 in occurrence was actually older than the virus prototype; and that the other recently found type 3 never attained wide circulation in the area during the 70-year observation period from the thirties to the present day. Thereby, the Bioportfolio constitutes at the individual level a new form of "medical record" for one's infectious encounters. At the global and epidemiological level, it provides a novel database for analysis of the occurrence and circulation of microbial species and their variants.

Furthermore, in light of the previously shown integrity and full-length coding potential of the persistent macromolecular viral DNA genomes, the Bioportfolio might provide the desired long-term permanence for gene therapy vectors, which in the future could be designed in accordance with this innate characteristic of the human body.

Norja P, Hokynar K, Aaltonen L-M, Chen R, Ranki A, Partio EK, Kiviluoto O, Davidkin I, Leivo T, Eis-HΓΌbinger AM, Schneider B, Fischer H-P, Tolba R, Vapalahti O, Vaheri A, Soderlund-Venermo M, Hedman K: Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue, PNAS April , 2006 (online).


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Cite This Page:

University of Helsinki. "Viral Genomic Material Remains In The Human Body Long After Infection." ScienceDaily. ScienceDaily, 7 May 2006. <www.sciencedaily.com/releases/2006/05/060507212454.htm>.
University of Helsinki. (2006, May 7). Viral Genomic Material Remains In The Human Body Long After Infection. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2006/05/060507212454.htm
University of Helsinki. "Viral Genomic Material Remains In The Human Body Long After Infection." ScienceDaily. www.sciencedaily.com/releases/2006/05/060507212454.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins