Featured Research

from universities, journals, and other organizations

Marijuana-derived Drug Suppresses Bladder Pain In Animal Models

Date:
May 21, 2006
Source:
University of Pittsburgh Medical Center
Summary:
IP 751, a potent synthetic analog of a metabolite of THC -- the principal active ingredient of marijuana -- effectively suppresses pain in hypersensitive bladder disorders such as interstitial cystitis, according to animal model study results presented today at the annual meeting of the American Urological Association.

IP 751, a potent synthetic analog of a metabolite of THC--the principal active ingredient of marijuana--effectively suppresses pain in hypersensitive bladder disorders such as interstitial cystitis (IC), according to animal model study results presented today at the annual meeting of the American Urological Association.

IP 751 is a potent anti-inflammatory and a powerful analgesic, although the mechanisms by which it works are unknown. However, since the drug is insoluble in water, its administration directly into the bladder is difficult.

For the study, researchers at the University of Pittsburgh School of Medicine addressed the hydrophobic properties of IP 751 by introducing the drug into a liposome, a tiny sac surrounded by fatty acids, allowing for the drug to be introduced directly into the bladders of rat models of varying degrees of bladder inflammation. IP 751 significantly suppressed bladder overactivity in both animal models. Bladder overactivity is the underlying cause of irritation and pain in the bladder.

"Interstitial cystitis is a difficult disease to treat, and not all treatments work well on all patients," said Michael B. Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine. "Any new option we can give our patients to alleviate their painful symptoms is very important."

According to the National Institute of Diabetes and Digestive and Kidney Diseases, 700,000 Americans have IC; 90 percent are women. IC is one of the chronic pelvic pain disorders, defined by recurring discomfort or pain in the bladder and surrounding pelvic region. Symptoms vary and can include any combination of mild to severe pain, pressure and tenderness in the bladder and pelvic area, and an urgent and/or frequent need to urinate. In IC, the bladder wall may become scarred or irritated, and pinpoint bleeding may appear on the bladder wall.

The study was supported by the NIH and the Fishbein Family Foundation Center of Urologic Research Excellence - Interstitial Cystitis (CURE-IC) Project. IP 751 was provided by Indevus Pharmaceuticals Inc. IP 751 is currently being considered for development by Indevus for specialty disease states, including interstitial cystitis, with additional applications in the treatment of pain and inflammation. Indevus Pharmaceuticals is a biopharmaceutical company engaged in the acquisition, development and commercialization of products targeting certain medical specialty areas, including urology and gynecology. Results are published in abstract 25.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Marijuana-derived Drug Suppresses Bladder Pain In Animal Models." ScienceDaily. ScienceDaily, 21 May 2006. <www.sciencedaily.com/releases/2006/05/060521103039.htm>.
University of Pittsburgh Medical Center. (2006, May 21). Marijuana-derived Drug Suppresses Bladder Pain In Animal Models. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2006/05/060521103039.htm
University of Pittsburgh Medical Center. "Marijuana-derived Drug Suppresses Bladder Pain In Animal Models." ScienceDaily. www.sciencedaily.com/releases/2006/05/060521103039.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins