Featured Research

from universities, journals, and other organizations

If The Chemistry Is Right ... You Might Remember This

Date:
May 26, 2006
Source:
Children's Medical Research Institute
Summary:
An Australian science team has made an interesting discovery that shows a fundamental mechanism of how nerve cells communicate. Their work, published in Nature Neuroscience, shows that a protein called syndapin plays a crucial part in nerve transmission in the brain. Scientists believe that syndapin could be targeted by medicines to treat seizures (e.g., epilepsy).

A young Australian scientist has made an important discovery about how brain cells communicate. This finding is central to understanding all brain function -- from laying down memory to being able to walk

The groundbreaking research has been published in the latest edition of world-leading journal Nature Neuroscience.

Victor Anggono, a PhD student at the Children's Medical Research Institute (CMRI), set out to identify the molecular partners of a key protein called dynamin, and how their partnership allows neurons to send messages.

The result was astounding. A protein called syndapin, previously thought to have no major role in nerve communication, was proven to be the molecule that simultaneously works with dynamin to allow the transmission of messages between nerve cells.

The brain functions by sending chemical messages between nerves. The messages, or neurotranmsitters, are held in tiny packages at the nerve terminal where they are released to send a signal. The packages then return to the cell and are re-filled so that brain function can continue.

In collaboration with researchers from the University of Edinburgh further studies have revealed that by blocking the interaction of these two proteins nerve communication shuts down.

"The partnership between dynamin and syndapin is crucial for the continous cycle of neurotransmission. This makes syndpain a very specific target for medicines that could treat conditions where there is an overload of nerve activity, such as during a seizures," said Dr. Phil Robinson leader of the research at the CMRI.

The relationship between dynamin and syndapin is also crucial to understanding other processes where there is a high level of brain activity and nerve transmission, such as when forming memories and during learning.

Dr. Robinson says, "A discovery like this will be vital for future research into many neurological disorders, such as epilepsy, conditions of memory loss and schizophrenia. It is only through research like this, that medical science can now target specific problems and develop improved treatments."

This research was funded through a grant from the National Health & Medical Research Council (NHMRC) and a scholarship from the University of Sydney as well as funds from the community donated to Jeans for Genes -- the major fundraising event of the CMRI.


Story Source:

The above story is based on materials provided by Children's Medical Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

Children's Medical Research Institute. "If The Chemistry Is Right ... You Might Remember This." ScienceDaily. ScienceDaily, 26 May 2006. <www.sciencedaily.com/releases/2006/05/060526090336.htm>.
Children's Medical Research Institute. (2006, May 26). If The Chemistry Is Right ... You Might Remember This. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2006/05/060526090336.htm
Children's Medical Research Institute. "If The Chemistry Is Right ... You Might Remember This." ScienceDaily. www.sciencedaily.com/releases/2006/05/060526090336.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins