Featured Research

from universities, journals, and other organizations

St. John's Wort Relieves Bladder Pain In Animal Models

Date:
May 29, 2006
Source:
University of Pittsburgh Medical Center
Summary:
St. John's Wort, an herbal supplement used for centuries, may be effective in relieving pain that occurs in hypersensitive bladder disorders such as interstitial cystitis (IC), according to animal model study results presented today at the annual meeting of the American Urological Association.

St. John's Wort, an herbal supplement used for centuries, may be effective in relieving pain that occurs in hypersensitive bladder disorders such as interstitial cystitis (IC), according to animal model study results presented today at the annual meeting of the American Urological Association.

Prior studies have found that neural control of the lower urinary tract is controlled by serotonin- and norepinephrine-emitting neurons, similar neurons to those that play a role in depression and anxiety. Researchers also have found that agonists and antagonists of serotonin and norepinephrine can be used to control urinary tract activity.

"St. John's Wort is an herbal supplement that has been used for years to treat symptoms of mild depression, while urologists often use antidepressants to treat interstitial cystitis," said Michael B. Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine. "Given that the supplement and the drug work on the same systems, it makes sense that St. John's Wort could help treat this painful disease."

For the study, the University of Pittsburgh researchers injected a formulation of St. John's Wort called DP015 into the abdomens of rats with bladder inflammation. As compared with controls, the models that were given DP015 showed an increased bladder contraction interval. Bladder hyperactivity, characterized by frequent contractions of the bladder, is a significant cause of irritation and pain in the bladder.

According to the National Institute of Diabetes and Digestive and Kidney Diseases, 700,000 Americans have IC; 90 percent are women. IC is one of the chronic pelvic pain disorders, defined by recurring discomfort or pain in the bladder and surrounding pelvic region. Symptoms vary and can include any combination of mild to severe pain, pressure and tenderness in the bladder and pelvic area; and an urgent and/or frequent need to urinate. In IC, the bladder wall may become scarred or irritated, and pinpoint bleeding may appear on the bladder wall.

The DP015 used in this study was supplied by Delithe Natural Products and the study was funded by the Fishbein Family Foundation Center of Urologic Research Excellence - Interstitial Cystitis (CURE-IC) Project.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "St. John's Wort Relieves Bladder Pain In Animal Models." ScienceDaily. ScienceDaily, 29 May 2006. <www.sciencedaily.com/releases/2006/05/060529082709.htm>.
University of Pittsburgh Medical Center. (2006, May 29). St. John's Wort Relieves Bladder Pain In Animal Models. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2006/05/060529082709.htm
University of Pittsburgh Medical Center. "St. John's Wort Relieves Bladder Pain In Animal Models." ScienceDaily. www.sciencedaily.com/releases/2006/05/060529082709.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins