Featured Research

from universities, journals, and other organizations

New Combination Treatment Induces Regression Of Prostate Cancer

Date:
June 8, 2006
Source:
Society of Nuclear Medicine
Summary:
A new treatment for prostate cancer may provide a distinct advantage over other conventional protocols and induce actual regression of the disease -- not just relief from bone pain or a limited control of the disease, according to a study by Italian researchers released at SNM's 53rd Annual Meeting June 3-7 in San Diego.

A new treatment for prostate cancer may provide a distinct advantage over other conventional protocols and induce actual regression of the disease--not just relief from bone pain or a limited control of the disease, according to a study by Italian researchers released at SNM's 53rd Annual Meeting June 3–7 in San Diego.

Related Articles


"A new treatment protocol combining radionuclide therapy and chemotherapy may represent a distinct advantage over conventional protocols, especially when patients have metastatic (or spreading) prostate cancer that is not responding to hormonal therapy," said Giuliano Mariani, professor of nuclear medicine and director at the Regional Center of Nuclear Medicine at the University of Pisa Medical School in Italy. "Radionuclide therapy alleviated bone pain, but preliminary observations indicated that--if adequately combined with chemotherapy--it might produce clinical benefit in terms of regression and prolonged survival," added the co-author of "Early Response and Toxicity of 153Sm-EDTMP Combined With Docetaxel in Patients With Hormone-Refractory Metastatic Prostate Cancer."

All men are at risk of developing cancer in the prostate, a gland in the male reproductive system. Prostate cancer occurs when the cells of the prostate begin to grow uncontrollably, and these cells may spread--or metastasize--from the prostate to other parts of the body, especially the bones and lymph nodes, said Mariani. More than 234,000 men in the United States will be diagnosed with prostate cancer this year, and more than 27,000 will die of the disease, which is the second leading cause of cancer death in men.

"We explored combining radionuclide therapy based on the radioisotope Samarium-153 with carrier EDTMP and chemotherapy to achieve actual regression and prolonged survival," said Mariani. "Our research confirms the possibility of achieving tumor targeting of a radiopharmaceutical with such efficiency that it induces a definite therapeutic effect, and this shows the possibility of obtaining a synergistic therapeutic effect in combination with conventional chemotherapy," he explained.

"The blood toxic effects of our combination regimen were mild and comparable to those observed when the two therapies were used separately," said Mariani. In addition, researchers "observed significant reduction of PSA (prostate-specific antigen) levels in serum, a marker of the overall burden or severity of the disease," he added. "The majority of patients treated so far have either stable disease or regression of disease in a six-month follow-up," he noted.

"A major concern when attempting combination regimens of this type is to induce reciprocal augmentation of the possible toxic effects of the two therapies (radionuclide and chemotherapy), thus limiting applicability of the new protocol," said Mariani. "We are now evaluating our patients with an extended follow-up in order to assess the effect of the combined protocol on survival. Future investigations should explore the possibility of employing higher doses of the radiopharmaceutical in order to achieve the highest possible therapeutic effect--with the lowest possible toxic effect, he noted.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "New Combination Treatment Induces Regression Of Prostate Cancer." ScienceDaily. ScienceDaily, 8 June 2006. <www.sciencedaily.com/releases/2006/06/060608132302.htm>.
Society of Nuclear Medicine. (2006, June 8). New Combination Treatment Induces Regression Of Prostate Cancer. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2006/06/060608132302.htm
Society of Nuclear Medicine. "New Combination Treatment Induces Regression Of Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/06/060608132302.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins