Featured Research

from universities, journals, and other organizations

Stem Cells Found In Adult Skin Can Be Transplanted And Function In Mouse Models Of Disease

Date:
June 14, 2006
Source:
University of Toronto
Summary:
-- Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The Journal of Neuroscience.

Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The Journal of Neuroscience.

SickKids researchers previously discovered what type of cells can be made from these stem cells (called skin-derived precursors, or SKPs) based on the role played by neural-crest stem cells during embryogenesis. In addition to generating the peripheral nervous system, neural crest stem cells generate other tissues such as bone, cartilage, some types of muscle, and even part of the heart.

In The Journal of Neuroscience paper, the research team found that SKPs can efficiently generate a type of glial cell, called Schwann cells, that can myelinate demyelinated axons (part of a neuron), and that have been shown to provide a good growth environment for injured central nervous system axons. These types of axons normally do not regenerate.

"Schwann cells have been proposed as a cell type for treatment of nerve injuries, demyelination disorders such as multiple sclerosis, and even spinal cord injury," said Dr. Freda Miller, the study's principal investigator, a senior scientist in Developmental Biology in the SickKids Research Institute, a professor of Molecular and Medical Genetics, and Physiology at the University of Toronto and Canada Research Chair in Developmental Neurobiology. "Our finding that we can efficiently generate and isolate these Schwann cells from SKPs raises the possibility that we could treat humans with Schwann cells derived from human skin stem cells, and perhaps even use the patient's own skin to generate Schwann cells for treatment."

The research showed that these SKP-derived Schwann cells can myelinate axons in culture, in the injured peripheral nerve, and even in the central nervous systems of mice that don't have myelin in their brains. While the research occurred in mouse models, some of their data indicate that human SKPs can do the same thing.

"Previous work has only dealt with SKPs in culture and their more basic biology. Now we have shown that SKPs can make at least one cell type that functions as predicted in animals," said Dr. Rajiv Midha, study author, a scientist at the Hotchkiss Brain Institute as well as chairman of the Division of Neurosurgery and professor and deputy head in the Department of Clinical Neurosciences at the University of Calgary. "This is the first time SKPs have been demonstrated to make bona fide neural cell types that can be transplanted into and function in animal models of disease."

Other members of the research team included Drs. Ian McKenzie, Jeff Biernaskie and Jean Toma, all from SickKids.

The next steps for the research team are to perform similar functional studies for the other cell types that they have shown are made by SKPs, including nerve cells, and to ask whether these SKP-derived Schwann cells can function in situations of human nervous system disease, such as spinal cord injury. On the basis of their findings, Dr. Miller and Dr. Wolfram Tetzlaff at the University of British Columbia have obtained a $1.5 million team grant from NeuroScience Canada's Brain Repair Program to determine whether human SKPs can be used to repair the injured spinal cord in rodents. The mission of NeuroScience Canada's Brain Repair Program is to fast-track neuroscience research in order to develop treatments and therapies more quickly.

This research was supported by the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Ontario, NeuroScience Canada, Parkinson Society Canada, the Stem Cell Network, the Stroke Network and SickKids Foundation.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University of Toronto. "Stem Cells Found In Adult Skin Can Be Transplanted And Function In Mouse Models Of Disease." ScienceDaily. ScienceDaily, 14 June 2006. <www.sciencedaily.com/releases/2006/06/060614112320.htm>.
University of Toronto. (2006, June 14). Stem Cells Found In Adult Skin Can Be Transplanted And Function In Mouse Models Of Disease. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2006/06/060614112320.htm
University of Toronto. "Stem Cells Found In Adult Skin Can Be Transplanted And Function In Mouse Models Of Disease." ScienceDaily. www.sciencedaily.com/releases/2006/06/060614112320.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins