Featured Research

from universities, journals, and other organizations

Gene Associated With Both Susceptibility And Disease Progression In Rheumatoid Arthritis

Date:
June 25, 2006
Source:
European League Against Rheumatism
Summary:
New research, announced recently at the 7th EULAR annual congress, reveals the Protein Tyrosine Phosphatase N22 (PTPN22) gene is associated not only with rheumatoid arthritis (RA) disease susceptibility, but also with disease progression, according to researchers from Norway and the Netherlands.

New research, announced recently at the 7th EULAR annual congress, reveals the Protein Tyrosine Phosphatase N22 (PTPN22) gene is associated not only with rheumatoid arthritis (RA) disease susceptibility, but also with disease progression, according to researchers from Norway and the Netherlands.

Related Articles


Whilst the missense polymorphism (1858C>T ; rs2476601) in the PTPN22 gene has recently been shown to be associated with risk of developing rheumatoid arthritis, as well as some other autoimmune diseases (such as lupus and type 1 diabetes), the potential influence of the gene on clinical outcomes has previously been unclear. As such, the study team aimed to investigate the extent to which the PTPN22 polymorphism was associated with the presence of autoantibodies and rate of radiographic progression in rheumatoid arthritis.

The team genotyped a cohort of 238 Norwegian rheumatoid arthritis patients (56% RF positive, aged between 20 to 70 years, with an average disease duration of 2.3 years). Radiographic damage was assessed by hand radiographs scored with the van der Heijde modified Sharp score (vdH Sharp score) by one reader.

Results from the study revealed RA association with carriage of the T allele (34.6 % in patients vs 21.4 % in controls; OR=1.94 (1.35-2.79), p= 0.0003) as well as an association between annual progression rate of vdH Sharp score and T-allele carriers (p=0.01).

No significant association was observed between the presence of the T-allele and either RF status (36% in RF+ vs 33% in RF-) or anti-CCP status (37% in anti-CCP+ vs 31% in anti-CCP-). To look for evidence of epistasis between PTPN22 and DRB1, the team also stratified for presence or absence of the shared epitope (SE), however no difference was seen between the two groups.

"Results from this study reveal the PTPN22 gene risk variant was associated with the progression rate for the articular damage" explained Dr. Benedicte Lie, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway, and the study's lead author. "Our findings indicate that this candidate gene is associated not only with disease susceptibility, but also with disease progression – a potentially valuable discovery in the search for effective treatments to treat and ultimately prevent onset of rheumatoid arthritis" she continued.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Gene Associated With Both Susceptibility And Disease Progression In Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 25 June 2006. <www.sciencedaily.com/releases/2006/06/060625122851.htm>.
European League Against Rheumatism. (2006, June 25). Gene Associated With Both Susceptibility And Disease Progression In Rheumatoid Arthritis. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2006/06/060625122851.htm
European League Against Rheumatism. "Gene Associated With Both Susceptibility And Disease Progression In Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2006/06/060625122851.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins